双能CT物质分离技术检测慢性肝炎患者肝脏铁沉积的应用研究  

The study of dual energy CT material decomposition technique for detection of hepatic iron in patients with chronic hepatitis

作　　者：马静[1] 严福华[2] 朱乃懿[2] 方佳[1] 宋法亮[1] 宋志强[1] 

机构地区：[1]石河子大学医学院第二附属医院兵团医院影像中心,新疆乌鲁木齐830000 [2]上海交通大学医学院附属瑞金医院放射科

出　　处：《实用放射学杂志》2014年第9期1549-1552,共4页Journal of Practical Radiology

基　　金：上海市科委医学引导项目（1241193000）.

摘　　要：目的 评价双能CT物质分离技术在观测慢性肝炎患者肝脏铁沉积中的应用价值.方法 前瞻性的入组51例慢性乙型病毒性肝炎患者.所有患者先后行上腹部双能CT扫描和3.0T MR多回波T2＊序列扫描.CT数据经后处理后得到铁分布图,并在该图像中测得铁叠加值（overlay值）.MR数据经后处理后测得R2＊值.overlay值与R2＊值行Spearman相关分析,并对诊断一致性进行Kappa检验.结果 overlay值与R2＊值有正相关性（r=0.709;P=0.000）.R2＊值诊断铁沉积的阳性率高于overlay值诊断的阳性率（P=0.031）,但2种诊断方法的一致性良好（Kappa值=0.768,P=0.000）.结论 双能CT物质分离技术可以作为一种可行的检测肝脏铁沉积的方法,为临床肝脏铁沉积的诊断、随访工作提供了另一种新的检测手段.Objective To explore the application value of dual energy CT material decomposition technique for detection of liver i- ron in patients with chronic hepatitis. Methods Both dual energy CT and MRI with multi echo T2＊ sequence scan were performed in 51 patients with chronic hepatitis. Overlay values and R2＊ values were respectively measured on generated virtual iron image and MR image after post-procession of the data. The overlay value and R2＊ value were analyzed by .qpearman correlation. Kappa test was done for diagnosis consistency. Results The overlay value was positively correlated to the R2＊value （ r=0. 709 ; P=0. 000 ）. The positive rate of R2＊ value for the diagnosis of hepatic iron deposition was higher than that of overlay value （P=0. 031）. The di- agnosis consistency of the two methods was well （Kappa value=0. 768,P=0. 000）. Conclusion Dual energy CT material decompo- sition technique may be a new feasible method for detection of hepatic iron in clinic.

关 键 词：计算机体层成像 物质分离 肝脏铁沉积 

分 类 号：R814.42[医药卫生—影像医学与核医学] R512.6[医药卫生—放射医学]