IGF-1R、IGFBP-1与妊娠期糖尿病巨大儿的相关性研究  

The correlation study of relativity between macrosomia of gestational diabetic pregnancy and IGF-1R,IGFBP-1

作　　者：谢伟姣 王敏[2] 于力[2] 陈秀芳[2] 宋丽萍[3] 周玲[1,2] 

机构地区：[1]安徽医科大学解放军306临床学院,北京100101 [2]中国人民解放军306医院妇产科,北京100101 [3]中国科学院微生物所,北京100101

出　　处：《安徽医科大学学报》2014年第10期1508-1510,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:30900759)

摘　　要：采用Real-Time PCR技术对妊娠期糖尿病(GDM)并分娩巨大儿胎盘22例(巨大儿组)和同期18例正常孕妇分娩正常体重儿(对照组)胎盘组织中胰岛素样生长因子-1受体(IGF-1R)以及胰岛素样生长因子结合蛋白-1(IGFBP-1)的mRNA进行检测,并分析两者与GDM巨大儿发生的相关性。结果显示巨大儿组患者胎盘中IGF-1R的表达量要显著高于对照组(P<0.05);胎盘中IGFBP-1的表达水平巨大儿组较对照组低,差异有统计学意义(P<0.05)。The mRNA of insulin-like growth factor 1 receptor （IGF-1R） and IGF binding protein-1（IGFBP-1） in the placenta of 22 macrosomia of gestational diabetic（ macrosomica group） and 18 normal birth weight infant（ control group） were measured by Real Time PCR,explored the relationship between macrosomia of gestational diabetic and the levels of IGF-1 R and IGFBP-1 . The level of IGF-1 R in the placenta of macrosomia group was significantly high-er than that of control group;the expression level of IGFBP-1 in the placenta of macrosomia group was lower than that of control group,and had significant difference between the two groups.

关 键 词：妊娠期糖尿病 巨大儿 胎盘 IGF-1R IGFBP-1 

分 类 号：R714.256[医药卫生—妇产科学]