IL-36γ、p38MAPK通路和Th17细胞因子在扁平苔藓中的表达  

Expression of IL-36 and p38MAPK pathway and Thl7 cytokine in lichen planus

作　　者：贺琪[1] 吴艳[1] 岳青[1] 李家文[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《中国麻风皮肤病杂志》2014年第9期515-518,共4页China Journal of Leprosy and Skin Diseases

基　　金：国家自然科学基金项目资助(编号:30972654)

摘　　要：目的:检测IL-36及p38丝裂原活化蛋白激酶(p38MAPK)通路和Th17细胞因子在扁平苔藓中的表达。方法:应用Envision免疫组化法检测58例扁平苔藓及19名正常皮肤标本中IL-36γ、磷酸化-p38MAPK(p-p38)和IL-17A的表达。结果:IL-36/、p-p38和IL-17A在扁平苔藓皮损中的蛋白表达阳性率为86.21%、79.31%和94.83%,显著高于正常对照标本阳性率为68.42%、15.79%和63.16%(均P<0.01)。扁平苔藓组中,IL-36γ与p-p38、IL-36/与IL-17A的表达水平存在显著正相关(P<0.001),两因子表达强度有显著差异(P<0.05)。结论:p38MAPK通路和Th17细胞因子可能与扁平苔藓的发病有关。Objective：To detect the expression of IL-36, p38 mitogen-activated protein kinase （ p-p38） pathway and Th17 cytokine in lichen planus. Methods：Immunohistochemistry EnVision technique was used to detect the expression of IL-36γ, p-p38 and IL-17A in 58 patients with lichen planus and 19 controls. Re-sults：The expression of IL-36γ, p-p38 and IL-17A was higher in the patients’ lesion of lichen planus （ the positive rates were 86.21%, 79.31% and 94.83%） than in control group （the positive rates were 68.42%, 15.79% and 63.16%） （ all P〈0.01） . In lichen planus group, there were positive correlations between the ex-pression of IL-36γand p-p38 （ P〈0.001） , and between the expression of IL-36γand IL-17A （ P〈0.001） . Significant difference was also observed between the two cytokines’ expression grade （ P〈0.05） . Conclusion：p38MAPK pathway and Th17 cytokine may be involved in the pathogenesis of lichen planus.

关 键 词：白细胞介素-36 扁平苔藓 P38丝裂原活化蛋白激酶 Th17细胞 白细胞介素-17A 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]