光动力疗法联合清痘修复精华液治疗中重度痤疮疗效评价  

Efficacy of photodynamic therapy with 5-aminolevulinic acid combined with anti-acne repairing essence in the treatment of moderate and severe acne

作　　者：刘刚[1] 熊俊浩[1] 王芳[1] 严蕾[1] 

机构地区：[1]四川省医学科学院.四川省人民医院皮肤病性病研究所,四川成都610072

出　　处：《中国麻风皮肤病杂志》2014年第9期527-529,共3页China Journal of Leprosy and Skin Diseases

基　　金：四川省卫生厅资助课题(编号:30305030658)

摘　　要：目的:评价5-氨基酮戊酸光动力疗法联合薇诺娜清痘修复精华液治疗中重度痤疮的临床疗效及安全性。方法:选取60例中重度痤疮患者随机分为2组:光动力组(对照组)和光动力联合清痘修复液组(治疗组),共治疗4周;在治疗后第2、4、6周对两组患者进行疗效评价,治疗结束后第3个月随访评估复发情况。结果:治疗2、4、6周后治疗组治愈率分别为67%,80%和93%,对照组治疗率分别为40%,60%和73%,两组差异显著(P<0.05)。治疗后随访治疗组复发率为7.14%,显著低于对照组的31.82%(P<0.05)。结论:ALA-PDT联合薇诺娜清痘修复精华液治疗中重度痤疮疗效好,复发率低且不良反应轻微。Objective：To assess the therapeutic efficacy and safety of ALA-PDT therapy combined with Winona anti-acne repair essence in the treatment of moderate and severe acne. Methods：Sixty patients with moderate to severe acne were randomly divided into two groups：photodynamic therapy combined with Winona group （ treatment group） and photodynamic therapy group （ control group） . The total duration of the treatment in both groups was 4 weeks. The clinical effects were assessed at the 2nd, 4th and 6th week after the treat-ment. At the 3rd month after the treatment recurrence was assessed. Results： At the 2nd, 4th and 6th week after the treatment the cure rates in the treatment group were 67%, 80%和93%, and the cure rates in the control group were 40%, 60%和 73%. The differences in the two groups were statistically significant （ P〈0.05） . The recurrence rates were 7.14% in the treatment group and 31.82% in the control group, with a sig-nificant difference in the two groups （ P〈0.05） . Conclusion：ALA-PDT combined with Winona anti-acne re-pair essence has higher efficacy, lower recurrence and mild side-effects in the treatment of moderate to severe acne.

关 键 词：痤疮 5-氨基酮戊酸 光动力疗法 薇诺娜清痘修复精华液 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]