miRNA与银屑病发病机制相关性研究进展  

miRNA and psoriasis:update in pathogenesis

作　　者：孙景英[1] 普雄明 吴卫东 

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]乌鲁木齐市自治区人民医院皮肤性病科,新疆830001

出　　处：《中国麻风皮肤病杂志》2014年第9期547-549,共3页China Journal of Leprosy and Skin Diseases

摘　　要：miRNA是长约18～25个核苷酸的非编码小RNA，通过与靶mRNA结合而抑制其表达或促进其降解。研究表明miRNA通过多种途径参与细胞的多种病理生理过程。银屑病是一种常见的慢性皮肤病，发病机制涉及遗传、感染及免疫等方面。文章综述了miRNA与银屑病发病机制相关性研究的进展。miRNA is non-coding, small, about 18～25 nucleotides length RNA, which inhibits the expres-sion of RNA or promotes degeneration of RNA through combining targeted mRNA. Studies have showed that miRNA is involved in many physiopathological procesess through a variety of ways. Psoriasis is a common chronic inflammatory skin disorder, and its pathogenesis is related to genetics, immunological and environ-mental factors. In this paper we focus on the relationship between miRNA and the pathogenesis of psoriasis.

关 键 词：MIRNA 信号通路 银屑病 发病机制 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]