瘦素及瘦素受体在银屑病皮损中的表达  

The expression of leptin and its receptor in the lesions of psoriasis

作　　者：黄朝卫[1] 杨洋[1] 刘新庭[1] 

机构地区：[1]黄石市中心医院普爱院区,435001

出　　处：《中国麻风皮肤病杂志》2014年第9期556-558,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:检测银屑病皮损中瘦素及其受体的表达。方法:40例银屑病患者皮损和18名正常人皮肤标本,采用SP免疫组化法检测皮肤石蜡标本中瘦素的表达,ELISA法检测瘦素受体的表达。结果:银屑病患者皮损中瘦素表达明显高于正常皮肤(P<0.01),主要分布在表皮的胞浆和胞核。患者皮损中瘦素受体含量为103.4±18.7 pg/mL高于正常对照组的76.9±13.5 pg/mL(P<0.05)。结论:瘦素及其受体可能参与了银屑病的发病。Objective：To detect the expression of leptin and its receptor in psoriastic lesions. Methods：The expression of leptin and its receptor in paraffin-embedded tissues from 40 patients with progressive psoria-sis and 18 healthy controls were detected using streptavidin-peroxidase immunohistochemistry methods and en-zyme-linked immunosorbent assay （ ELISA） . Results：The expressions of leptin was significantly higher in pa-tients with psoriasis than that in controls （ P〈0.01） . Leptin receptor level was significantly higher in patients with psoriasis than that in controls （P〈0.05）. Conclusion： Leptin and its receptor may be involved in the pathogenesis of psoriasis.

关 键 词：银屑病 瘦素 瘦素受体 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]