氟比洛芬酯微球制剂复合芬太尼术后静脉镇痛效果  

Efficacy of postoperative analgesia with flurbiprofen axetil and fentanyl

作　　者：陈小红[1] 曹苏[2] 曹汉忠[1] 

机构地区：[1]南通市肿瘤医院麻醉科,江苏省226361 [2]南通大学附属医院麻醉科

出　　处：《江苏医药》2014年第19期2316-2318,共3页Jiangsu Medical Journal

摘　　要：目的观察氟比洛芬酯微球制剂复合芬太尼术后患者自控静脉镇痛(PCIA)效果。方法宫颈癌根治术患者240例随机均分为两组:A组PCIA采用氟比洛芬酯复合芬太尼(氟比洛芬酯300mg+芬太尼1.2mg);B组PCIA单用芬太尼(芬太尼2.4mg)。两组均用生理盐水配置成150ml,持续输注量2ml/h;PCIA单次量2ml/次,锁定时间10min。记录术后12、24、48和72h的VAS疼痛评分、Ramsay镇静评分和不良反应发生情况。并于镇痛治疗前后采用Sonoclot凝血与血小板功能分析仪评定凝血功能。结果 A组术后12h和24h的VAS疼痛评分低于B组(P<0.01),而Ramsay镇静评分高于B组(P<0.01);但术后48h和72h的VAS疼痛评分和Ramsay镇静评分相仿(P>0.05)。术后A组PCIA按压次数少于B组(P<0.01)。两组镇痛期血小板功能与术前相仿(P>0.05)。A组不良反应发生率低于B组(P<0.05)。结论氟比洛芬酯微球制剂复合芬太尼用于术后PCIA优于单用芬太尼。Objective To observe the efficacy of postoperative analgesia with flurbiprofen axetil and fentafiyl. Methods The patient-controlled intravenous analgesia（PCIA） was performed in 240 patients after radical surgery for cervical cancer, who were equally randomized into two groups of A （PCIA with flurbiprofen 300 mg plus fentanyl 1.2 mg） and B（PCIA with fentanyl 2.4 rag）. The analgesic silution was diluted up to 150 ml with normal saline and infused in a dose of 2 ml/h with PCIA dose of 2 ml once in 10 rain. VAS and Ramsay sedation scores were recorded at 12,24,48 h and 72 h during analgesia. The coagulation indicators of activated whole blood clotting time, coagulation rate and platelet function were detected with Sonoclot coagulation and platelet function analyzer before and during PCIA. Results VAS scores were lower,and Ramsay scores were higher,at 12 h and 24 h in group A than those in group B （P〈0. 01 ）, which of two groups at 48 h and 72 h were similar （P〉0. 05）. The number of PCIA Compression was less in group A than that in group B（P〈0. 01）. The platelet function of two groups was similar during PCIA （P〉0. 05）. The incidence of adverse responses was lower in group A than that in group B（P〈0. 05）. Conclusion Compared with fentanyl alone,PCIA with combined use of flurbiprofen and fentanyl is better.

关 键 词：氟比洛芬酯 芬太尼 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]