自组装肽纳米纤维支架用于骨修复的研究进展  

RESEARCH PROGRESS OF SELF-ASSEMBLING PEPTIDE NANOFIBER SCAFFOLD FOR BONE REPAIR

作　　者：何彬[1] 袁霄[2] 张华[1] 蒋电明[1] 

机构地区：[1]重庆医科大学附属第一医院骨科,重庆400016 [2]重庆医科大学附属第一医院心内科,重庆400016

出　　处：《中国修复重建外科杂志》2014年第10期1303-1306,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81171685)~~

摘　　要：目的对自组装肽纳米纤维支架的生物学特性及用于骨修复的研究进展进行综述。方法广泛查阅近年国内外有关自组装肽纳米纤维支架和骨修复研究的文献,并进行综合分析和总结。结果自组装肽纳米纤维支架由氨基酸构成,具有良好的生物相容性,其降解产物无毒性。自组装肽纳米纤维形成的微环境与细胞外基质高度相似,且生长因子的控释和功能基序的修饰显著提高了该材料的生物活性。大量体外细胞复合培养及动物体内骨缺损修复实验结果显示,该支架可促进细胞的黏附、增殖和分化,且有利于体内新骨组织形成。结论自组装肽纳米纤维支架有望成为理想的骨修复材料,但其生物力学性能有待进一步提高。Objective To review the biological characteristics of self-assembling peptide nanofiber scaffold（SAPNS） and its potential to induce bone repair. Methods The literature regarding SAPNS and its application in bone repair was extensively analyzed and reviewed. Results SAPNS is derived from natural amino acids, and has the properties of good biocompatibility and non-toxic degradation products. Their microenvironment highly mimics the natural extracellular matrix, and controlled release of growth factors as well as modification with functional motifs can substantially improve their bioactivity. Many studies on cell composite culture and bone defect repair of animal models reveal that SAPNS has the ability to promote the function of bone cells（e.g. adherence, proliferation, and differentiation） in vitro, and enhance new bone tissue formation in vivo. Conclusion SAPNS may be an ideal material for bone repair, but its biologically mechanical properties need further improvement.

关 键 词：分子自组装 自组装肽纳米纤维支架 骨修复 

分 类 号：R318.08[医药卫生—生物医学工程]