绝经激素治疗与代谢综合征风险研究进展  

Menopause hormone therapy and risk of metabolic syndrome

作　　者：阮祥燕[1] 崔亚美[1] Diethelm Wallwiener Alfred O.Mueck 

机构地区：[1]首都医科大学附属北京妇产医院内分泌科,北京100026 [2]德国图宾根大学妇产医院内分泌与绝经中心,德国图宾根d72076

出　　处：《首都医科大学学报》2014年第4期387-391,共5页Journal of Capital Medical University

基　　金：国家自然科学基金(30872745);北京市自然科学基金(3082011);北京市卫生系统高层次卫生技术人才培养计划项目(2009-3-52);首都医科大学附属北京妇产医院;北京妇幼保健院学科带头人项目(2013-1)~~

摘　　要：代谢综合征(包括腹型肥胖、糖代谢异常、脂代谢紊乱、高血压等)因与心血管病风险因素密切相关,已成为全球公共健康的一个主要挑战。绝经后激素治疗的应用已有半个多世纪,但绝经后激素治疗(menopause hormone therapy,MHT)的适应证及理想候选适应证仍然不清楚。绝经妇女心血管病风险的增高是这组人群死亡的主要原因。雌激素的降低与许多围绝经与绝经后妇女总胆固醇、三酰甘油、低密度脂蛋白胆固醇的增加,胰岛素抵抗的增加及血压的升高相关。这些变化的参数是代谢综合征的主要组分。目前推荐MHT作为血管舒缩症状的金标准治疗,其对代谢综合征组分及心血管病风险的益处仍不清楚,本文将对MHT与代谢综合征组分的风险及益处进行综述。The metabolic syndrome （ including visceral obesity , dyslipidemia , hyperglycemia , and hypertension ） has become one of the major public-health challenges worldwide .The menopause hormone therapy （ MHT） is in use for more than a half of century , but the question of indications and ideal candidates for hormone replacement therapy （ HRT ） remains unclear .Postmenopausal women are a population with the increasing risks for cardiovascular diseases which are the main cause of death in this group .Decline in estrogen concentrations is linked to a number of changes in peri and postmenopause： increased total cholesterol , triglycerides , and low density lipoprotein, increased insulin resistance and increased blood pressure etc .These changes are the main components of metabolic syndrome . HRT is currently recommended as the gold standard for the management of vasomotor symptoms , but the benefit of MHT on components of metabolic syndrome and risk for cardiovascular events risk is still uncertain .This review will focus on MHT risk and benefit issues .

关 键 词：代谢综合征 绝经激素治疗 肥胖 血脂异常 高血糖 高血压 

分 类 号：R711[医药卫生—妇产科学]