新生儿肺出血预后影响因素分析  

Analysis of factors in outcomes of infants with pulmonary hemorrhage

作　　者：郑丽玲[1] 吴斌[2] 

机构地区：[1]福建医科大学附属漳州市医院儿科,福建漳州363000 [2]福建医科大学附属第一医院儿科,福建福州350001

出　　处：《临床儿科杂志》2014年第9期812-815,共4页Journal of Clinical Pediatrics

摘　　要：目的：探讨影响新生儿肺出血预后的相关因素。方法选择2005年1月至2011年12月住院治疗的69例确诊为肺出血的新生儿为研究对象，根据临床预后分为死亡组和存活组，对两组患儿的临床特征进行单因素分析，筛选出关联因素，并以此为基础，进行非条件Logistic多元回归模型分析。结果单因素分析表明，新生儿肺出血死亡与吸入性肺炎、高胆红素血症、弥漫性血管内凝血、心力衰竭及血小板平均体积（MPV）相关联。多元回归模型提示患儿有弥漫性血管内凝血（OR=6.90，95%CI：1.51-31.42）和心力衰竭（OR=9.62，95%CI：1.71-54.15），以及肺出血前MPV〈11 fl（OR=7.01，95%CI：1.48-33.31），是肺出血死亡的独立危险因素。结论对并存弥漫性血管内凝血、心力衰竭及MPV值低的新生儿肺出血应采取更积极的干预措施。Objective To investigate the risk factors in the outcome of neonatal pulmonary hemorrhage. Methods A total of 69 cases of neonatal pulmonary hemorrhage from January 2005 to December 2011 were studied. They were divided into 2 groups according to clinical outcome （death or alive）. The data of the two groups were compared using single factor analysis. The risk factors were analyzed using multi-factor analysis. Results The death of neonates with pulmonary hemorrhage was correlated with aspiration pneumonia, coagulation abnormalities, DIC, heart failure and MPV. Multi-factor analysis showed that DIC （OR=6.90, 95%CI：1.514-31.419）, heart failure （OR=9.62, 95%CI：1.710-54.150） and MPV〈11 prior to pulmonary hemorrhage （OR=7.01, 95%CI：1.475-33.312） were the independent risk factors of neonatal pulmonary hemorrhage. Conclusions For the neonatal pulmonary hemorrhage with DIC, heart failure and low MPV, active intervention should be implemented.

关 键 词：新生儿肺出血 死亡 高危因素 Logistic多元回归模型 

分 类 号：R722.1[医药卫生—儿科]