螨过敏咽炎患者舌下脱敏的疗效及其影响因素分析  

The effect and the analysis of the influence factors of sublingual immunotherapy on patients with pharyngitis and allergy to house dust mite

作　　者：陈玉赞[1,2] 

机构地区：[1]安徽医科大学附属安庆医院 [2]安庆市立医院耳鼻咽喉科,安徽安庆246003

出　　处：《临床耳鼻咽喉头颈外科杂志》2014年第19期1511-1513,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:评估舌下特异性免疫治疗(SLIT)螨过敏咽炎患者是否起效,探讨不同治疗方案、单一和多重过敏、性别等因素是否对SLIT起效有影响。方法:对我院53例螨过敏咽炎患者,进行治疗前和治疗6个月后的药物总评分(TMS)和治疗6个月后的患者自我疗效评价。根据给药方案将试验组分为SLIT组、综合组;根据点刺结果将试验组分为尘螨组和多重组;根据性别将试验组分为男性组和女性组。将25例仅接受对症药物治疗的患者作为对照组。将对照组和试验组以及试验组中不同各组在治疗6个月后的有效率和TMS减少比例进行比较。结果:试验组有效率和TMS减少比均高于对照组,差异有统计学意义(P<0.01)。SLIT组有效率为72.73%,综合组为76.47%,两者差异无统计学意义(P>0.05);尘螨组有效率和TMS减少比分别为61.54%和94.46%,多重组分别为66.67%和71.25%,2组有效率和TMS减少比比较,差异无统计学意义(P>0.05);女性组有效率和TMS减少比分别为83.33%和97.04%,男性组分别为58.33%和66.67%,2组有效率差异无统计学意义(P>0.05),而2组TMS减少比差异有统计学意义(P<0.05)。结论:SLIT对螨过敏咽炎患者有效;治疗方案,单一和多重过敏对SLIT治疗螨过敏咽炎患者无影响,性别有一定影响。Objective：To evaluate the effect of sublingual specific immunotherapy（SLIT）on patients with pharyngitis and allergy to house dust mite and to discuss the influence of different treatments,single and multiple allergen sensitization and genders on SLIT.Method：We recorded the total medicine score（TMS）and self evaluation of 53 patients with pharyngitis and allergy to house dust mite before and 6months after the treatment.Control group included 25 patients only treated with anti-allergic drugs.Treatment group included 28 patients accept SLIT.Based on different dosage regimens,treated patients were divided into SLIT group and comprehensive group;Based on the results of skin prick,treated patients were divided into dust mite group and multiple group;Based genders,treated patients were divided into male and female group.We compared the effective rate（ER）and decreasing percent of TMS（Dp-TMS）between control and treatment group,and also different groups in treatment group.Result：The ER and Dp-TMS of treatment group is significantly higher than control group,（P〈0.01）.The ER of SLIT and comprehensive group respectively is 72.73%and 76.47%without significant difference（P〉0.05）.The ER and Dp-TMS of dust mite group and multiple group respectively is 61.54%,94.46%,66.67%,71.25% without significant difference（P〉0.05）.The ER and Dp-TMS of male and female respectively are58.33%,66.67%,83.33%,97.04% with significant difference（P〉0.05）,while the Dp-TMS is not（P〉0.05）.Conclusion：The SLIT is effective to patients with pharyngitis and allergy to house dust mite;The therapeutic schedule,single and multiple allergen sensitization have no effects on SLIT in patients with pharyngitis and allergy to house dust mite.However,genders have influence on it.

关 键 词：舌下特异性免疫治疗 咽炎 尘螨 

分 类 号：R766.14[医药卫生—耳鼻咽喉科]