完全液体通气联合体外无泵膜肺氧合应用治疗心脏体外循环术后重症肺损伤的实验研究  

EXPERIMENTAL EFFECTS OF TOTAL LIQUID VENTILATION COMBINATION OF PUMPLESS EXTEACORPOEAL MEMBRANCE OXYGENATION AFTER RESPIRATORY DISTRESS SYNDROME IN PIGLETS

作　　者：高荣[1] 赵龙[1] 祝志川[1] 张华锋[1] 

机构地区：[1]内蒙古医科大学附属医院心脏大血管外科,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2014年第4期330-333,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金(2010BS1103)

摘　　要：目的:评估完全液体通气联合体外无泵膜肺氧合应用在心脏体外循环术后重症肺损伤的动物模型效果。方法:本实验以小型实验猪为实验对象,建立肺损伤动物模型,分别和联合应用完全液体通气与体外无泵膜肺氧合技术,通检测血流动力学和肺功能指标。结果:完全液体通气组能改善供氧,降低肺组织促炎细胞因子的表达,但在CO2排放方面能力有限;ECMO氧合作用明显低于CO2排除,而二者联合后动物的血流动力学稳定,呼吸动力学与肺换气功能得以有效地改善。结论:完全液体通气与体外无泵膜肺氧合联合应用可使肺损伤动物模型呼吸动力学和肺功能得以有效地改善。Objective： To detect liquid ventilation combination of pumpless exteacorpoeal membrance oxygenation （ ECMO ） after respiratory distress syndrome in piglets. Methods：20 health piglets were randomly divided into four group. normal group,total liquid ventilation group,ECMO group and both method group. Blood gas,hemodynamics index,lung function index and plasma levels of IL-8,IL-10 were evaluated. Results：There were significant differences in the cardiac output, lung function,inflammatory cytokine and anti-inflammatory cytokine in four groups. The level of CO2 was lower in total liquid ventilation group. The level of O2 was lower in ECMO group. Conclusion：Total liquid ventilation combination of ECMO can increase cardiac output,improving lung function,increasing anti-inflammatory cytokine and decreasing inflammatory cytokine.

关 键 词：完全液体通气 体外无泵膜肺氧合 肺损伤 

分 类 号：R655[医药卫生—外科学]