煤基碳基固体酸催化合成1,2取代苯并咪唑类衍生物  

Synthesis of 1,2-disubstituted benzimidazole derivatives by sulfonated coaled carbon-based solid acid

作　　者：谢昊[1] 吴淑萍[1] 何康丽 刘万毅[1] 李锐[2] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021 [2]宁夏大学能源重点实验室,宁夏银川750021

出　　处：《化学研究与应用》2014年第10期1584-1590,共7页Chemical Research and Application

基　　金：国家自然科学基金项目(Nos.21166021;51364038)资助

摘　　要：以太西煤为原料(其灰份为0.6%、目数大于200目),通过直接磺化得到煤基碳基磺酸(CHS-SA),以及通过对太西无烟煤粉末与煤质腐植酸钠粘合成型后的碳化物进行磺化而得的复配型煤基碳基固体酸(CCBSA),考察了2种煤基碳基固体酸催化邻苯二胺(OPDA)与芳香醛缩合制备1,2取代苯并咪唑类衍生物的合成工艺参数。结果表明CCB-SA的催化活性优于CHS-SA。优化出的反应条件是:邻苯二胺与芳香醛的投料当量比为1mmol∶2mmol,乙醇与水2∶1体积比的混合溶剂5mL,CCB-SA用量为反应底物总重量的31%,在回流条件下反应35-70 min时,目标产物的收率可达78%-86%。该类催化剂在水介质中对反应具有较好的催化活性、且可以重复利用3次。In this study,sulfonating coaled carbon-based solid acid catalyst（ CHS-SA） was prepared by means of Taixi coal（ ash con-tent is 0. 6%,mesh＆gt;200）as the main raw resource directly,as well as get through sulfonating the carbides from Taixi coal powder bonded with coal-based sodium humate to form composite coaled carbon-based solid acid catalyst（CCB-SA）. Both coaled carbon-based solid acid catalyst had been investigated for their synthesis parameters in the condensation reaction between o-phenylenedia-mine（OPDA）and aromatic aldehyde to synthesize 1,2-substituted benzimidazoles. The result showed the catalytic activity of CCB-SA was higher than CHS-SA. The optimization reaction conditions were：n（OPDA）∶n（aldehyde）=1∶2,V（EtOH）∶V（water）=2∶1 （5mL）,the quantity of CCB-SA equaled to 31%feed stock,refluxing reaction time 35-70 min,its yield could reach 78%-86%. The catalyst had good catalytic performance in the aqueous media,and repeated for three times without loss of activity.

关 键 词：邻苯二胺与芳香醛 缩合反应 1  2-取代苯并咪唑 太西煤 碳基磺酸固体酸 

分 类 号：O625.6[理学—有机化学]