N,N,N'-不同基团三取代乙二胺衍生物的简便合成  

A convenient synthesis of N,N,N'-trisubstituted ethylenediamine derivatives

作　　者：郭文彦[1,2] 陈建新[1] 温雪山[1] 赵艳亲[1] 王映霞[1] 

机构地区：[1]山西师范大学化学与材料科学学院,山西临汾041004 [2]山西师范大学现代文理学院,山西临汾041000

出　　处：《化学研究与应用》2014年第10期1683-1688,共6页Chemical Research and Application

基　　金：山西省自然科学基金项目(2012011046-9)资助;囯家大学生创新创业基金项目(201210118003)资助

摘　　要：以2-取代咪唑啉为起始原料,经过磺酰化反应,得到磺酰基咪唑啉2a-2e,然后进行甲基化反应得到1,2,3-三取代咪唑啉碘盐3a-3e。化合物3在室温下经过水解反应或还原反应,可得到两类不同基团N,N,N'-三取代乙二胺衍生物4或5。该反应具有条件温和、副产物少、产物得率高和后处理简单等优点,提供了一种有效的三步合成不同基团N,N,N'-三取代乙二胺衍生物的新方法。所合成产物通过NMR、IR和元素分析方法进行了结构确证。Using 2-substituted 4,5-dihydroimidazole as the starting material,arylsulfonyl imidazolines 2a-3e were obtained by the treatment with arylsulfonyl chloride. Then 2a-3e were methylated by iodomethane to afford 1,2,3-trisubstituted imidazolinium io-dides 3a-3e. After hydrolysis reaction or reduction reaction at room temperature,compounds 3 were converted into two types of N, N,N′-trisubstituted ethylenediamine derivative containing different groups. Their structures were confirmed by NMR,IR and elemen-tal analysis. The main advantages of the developed methodology were mild reaction conditions,less byproducts,high yields of prod-ucts and simple work-up procedure. An effective three-step synthesis method of N,N,N′-trisubstituted ethylenediamine derivative containing different groups had been developed.

关 键 词：咪唑啉 三取代乙二胺 合成 水解 还原 

分 类 号：O621.3[理学—有机化学]