SLE患者检测hsCRP的临床意义  

High Sensitivity C-reactive Protein(hsCRP):Association with Clinical Subsets in Systemic Lupus Erythematosus(SLE)Patients

作　　者：赵春梅[1] 王彦焱[1] 罗莉[1] 

机构地区：[1]新疆医科大学第一附属医院风湿科,乌鲁木齐830054

出　　处：《四川解剖学杂志》2014年第2期1-3,共3页Sichuan Journal of Anatomy

基　　金：新疆维吾尔自治区自然科学基金青年项目(20131029974)

摘　　要：目的探讨系统性红斑狼疮(SLE)患者超敏C反应蛋白(hsCRP)与病情及补体间的关系。方法对115例系统性红斑狼疮的患者,采用系统性红斑狼疮疾病活动指数(SLEDAI)评估狼疮病情。采用比浊法检测超敏C反应蛋白和补体水平。结果 115例患者中有42例(36.5%)超敏C反应蛋白升高,超敏C反应蛋白增高与感染相关(P<0.001),伴有细菌、病毒、寄生虫感染的患者超敏C反应蛋白增高。狼疮性肾炎组超敏C反应蛋白(29.21±3.82)mg/L较非狼疮性肾炎组(27.23±2.46)mg/L轻度增高,但结果无统计学意义。超敏C反应蛋白增高组的患者较正常组患者,补提水平显著减低(P=0.03)。结论超敏C反应蛋白增高与系统性红斑狼疮患者合并感染及低补体血症相关。超敏C反应蛋白可以作为评估狼疮患者是否合并感染的有效指标。Objective This survey was made to investigate and analyze the association between hsCRP and SLE disease manifestations and Complement. Methods A total of 115 SLE patients were studied and SLE disease activity was evaluated by SLE Disease Activity Index （SLEDAI）. hsCRP and complement levels were detected by nephelometer. Results The elevated hsCRP （42/115, 36.5%） was associated with presence of infection （P〈0. 001）. Patients having bacterial, parasitic and viral infections had elevated levels of hsCRP. SLE patients showed slightly higher hsCRP levels （29.21±3.82mg/l） mg/L than non-SLE group（27.23±2.46） mg/L but this difference was not significant. Patients with raised hsCRP levels showed a higher prevalence of low complement levels as compared to patients with normal CRP levels （P=0.03）. Conclusion Elevated hsCRP levels were found to be associated with infections in SLE patients and low complement levels, which can be used as a marker of active infection in SLE patients.

关 键 词：系统性红斑狼疮 超敏C反应蛋白 补体 狼疮性肾炎 

分 类 号：R593.241[医药卫生—内科学]