窒息新生儿血小板参数与脑血流动力学变化的关系及临床意义  

Relationship between platelet parameters and cerebral hemodynamic changes of neonates with asphyxia and the clinical significance

作　　者：邓刚[1] 胡海燕[1] 杨华英[1] 

机构地区：[1]四川省自贡市妇幼保健院,四川自贡643000

出　　处：《中国妇幼保健》2014年第30期4938-4939,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨窒息新生儿血小板参数及脑血流动力学变化的关系及临床意义。方法:选取轻度窒息新生儿28例和重度窒息新生儿19例,分别应用全自动血细胞分析仪和经颅多普勒超声动态检测新生儿的血小板参数、大脑中动脉的血流动力学参数,分别按窒息程度进行比较。结果:重度与轻度窒息新生儿血小板(PLT)显著降低,血小板平均体积(MPV)与血小板体积分布宽度(PDW)明显增高,与轻度窒息新生儿比较,差异有统计学意义(P<0.05)。重度窒息新生儿发生显著的脑血流动力学改变,血流速度减慢,阻力指数(RI)增加,与轻度窒息新生儿比较,差异有统计学意义(P<0.05)。结论:血小板参数及脑血流动力学的变化对窒息后脑损伤的诊断及病情评估具有指导意义。Objective： To explore the relationship between platelet parameters and cerebral hemodynamic changes of neonates with asphyxia and the clinical significance. Methods： A total of 28 neona;es with mild asphyxia and 19 neonates with severe asphyxia were selected. The platelet parameters and middle cerebral artery hemodynamic parameters were detected by automatic hematology analyzer and transeranial Doppler ultrasound, respectively, then the parameters were compared. Results： The count of platelet in neonates with severe asphyxia decreased significantly, mean platelet volume （MPV） and platelet volume distribution width （PDW） increased significantly, compared with the neonates with mild asphyxia, there were statistically significant differences （ P 〈 0.05 ） . Cerebral hcmodynamic changes of neonates with severe asphyxia were significant, the blood flow velocity slowed, resistance index （RI） increased, compared with the neonates with mild asphyxia, there were statistically significant differences （P 〈 0. 05 ） . Conclusion： Platelet parameters and cerebral hemodynamic changes have guiding significance in diagnosis and condition assessment of brain injury after asphyxia.

关 键 词：窒息 新儿生 血小板参数 脑血流动力学 

分 类 号：R722[医药卫生—儿科]