细胞穿膜肽作为皮肤渗透促进剂的研究进展  

Progress in Researches for Cell-Penetrating Peptides as Skin Penetration Enhancer

作　　者：郭霞[1] 曾珊珊[1] 叶金翠[1] 

机构地区：[1]浙江省医学科学院药物研究所,杭州310013

出　　处：《中国药学杂志》2014年第19期1677-1681,共5页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(30901871);卫生部科研基金(201231507);浙江省科技厅项目(2011C13003;2014F10034);浙江省卫生高层次创新人才培养工程项目;浙江省医学重点学科群建设(XKQ-010-001)

摘　　要：目的综述细胞穿膜肽作为皮肤渗透促进剂的研究进展。方法参考近年来国内外相关文献,对细胞穿膜肽的起源、分类以及在经皮给药系统中的应用等进行综述。结果细胞穿膜肽是具有细胞膜穿透能力的小肽,能有效地促进核酸类、肽类、蛋白质类等生物大分子药物经皮吸收。结论细胞穿膜肽作为一种新型的透皮给药渗透促进剂有巨大潜在的应用价值,但其促透机制需要更深入的研究。OBJECTIVE To review the progress in researches for cell-penetrating peptides as skin penetration enhancer. METHODS Based on the literatures in recent years published at home and abroad, the origin, classification and application of cell- penetrating peptides in the field of transdermal drug delivery system were introduced in the present paper. RESULTS Cell-penetrat- ing peptides are small peptides that are able to transfer nucleic acids, peptides and proteins into skin effectively. CONCLUSION As a novel skin penetration enhancer, the cell-penetrating peptides has enormous potential application value, but the mechanism of promo- tin- penetration requires further study.

关 键 词：细胞穿膜肽 渗透促进剂 经皮给药系统 生物大分子药物 

分 类 号：R944[医药卫生—药剂学]