微量白蛋白尿与糖尿病视网膜病变的相关性研究  

The study on the relationship between the urinary microalbumin and diabetic retinopathy

作　　者：张莉[1] 孟梅霞[1] 安军民[1] 王润生[2] 张媛[1] 畅飞[1] 

机构地区：[1]西安市第四医院肾脏内科,陕西西安710004 [2]西安市第四医院眼科,陕西西安710004

出　　处：《西部医学》2014年第10期1295-1298,共4页Medical Journal of West China

基　　金：陕西省西安市卫生局科技项目(2009D2)

摘　　要：目的 了解尿微量白蛋白测定在预防糖尿病视网膜病变（DR）中的意义.方法 对150例住院的Ⅱ型糖尿病患者（T2DM）,根据眼底情况分为正常眼底组（NR）,背景型糖尿病视网膜病变组（BDR）和增殖性糖尿病视网膜病变组（PDR）;对所有患者均检测尿白蛋白/肌酐比（ACR）;根据ACR的值分为正常白蛋白尿组（NA）,微量白蛋白尿组（MAU）,大量白蛋白尿组（CAU）.结果 150例Ⅱ型糖尿病患者中有125倒（83.3％）合并不同程度的DR,且其严重程度与病程呈正相关;ACR在30～300mg/g之间,有90.2％患者发生DR,ACR＞ 300mg/g,DR的发生率为100％.结论 Ⅱ型糖尿病患者DR发生与蛋白尿水平和病程密切相关,尿微量白蛋白可成为预测DR严重程度的指标之一.Objective To investigate the relationship between urinary microalbumin and diabetic retinopathy （DR）.Methods 150 type 2 diabetic inpatients were divided into normal retina （NR）,background diabeticretinopathy （BDR） and Proliferative diabetic retinopathy （PDR） according to the fundus.All the patients had to accept the urinary albumin/urinary creatinine rate（ACR）,according to which they were divided into normal albuminuria group （NA）,microalbuminuria group（MAU） and macroalbuminuria group（CAU）.Results For the 150 type 2 diabetic inpatients,83.3% （125/150） were complicated with different degrees of DR,which were positively correlated with diabetes duration.ACR between 30-300mg/g,the prevalence of DR account for 90.2%,and 100% when the ACR was more 300mg/g.Conclusions Albuminria,diabetes duration were dependent risk factors of DR in type 2 diabetic patients; Urinary microalbumin is one of the reliable markers forecasting and reflecting the degree of DR.

关 键 词：Ⅱ型糖尿病 糖尿病视网膜病变 尿微量白蛋白 

分 类 号：R587.1[医药卫生—内分泌] R774.1[医药卫生—内科学]