青春期双酚A暴露对CD-1小鼠种属行为的影响  

Effects of adolescent exposure to bisphenol A on species-typical behaviors in the aged CD-1 mice

作　　者：葛海[1] 吴鹏超[1] 曹磊[1] 陈贵海[1] 

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《安徽农业大学学报》2014年第5期805-807,共3页Journal of Anhui Agricultural University

基　　金：国家自然科学基金(30872730;81370444)资助

摘　　要：利用储藏、挖掘和作窝实验检测青春期暴露双酚A(BPA)对老年CD-1小鼠种属行为的影响。结果显示老年对照组的储藏、挖掘和做窝能力均较青年对照组下降(P<0.05)。BPA处理高剂量组和低剂量组雌鼠的储藏能力都较老年对照雌鼠下降(P<0.05),高剂量组总体及雌鼠的挖掘能力显著低于相应对照(P<0.05)。上述结果提示老年CD-1小鼠可能具有普遍性种属行为抑制,青春期BPA暴露对于老年CD-1小鼠种属行为有性别和任务特异性损害作用。In this study, the tasks of hording, burrowing, and nesting were used to evaluate the effect of ado-lescent bisphenol A exposure on the species-typical behaviors in the aged CD-1 mice. The results showed that theabilities of hording, burrowing, and nesting in the old group significantly reduced （Ps 〈 0.05） compared to theyoung group. The hording abilities significantly reduced in the females exposed to a high- and low-dose BPA dur-ing puberty compared to the corresponding old controls （P 〈 0.05）. The overall performance of the burrowingabilities in the high-dose group and the females significantly decreased than those in the corresponding controls（Ps 〈 0.05）. These results suggested that old CD-1 mice might have a general species-typical behavioral inhibition.Adolescent exposure to BPA could impair the species-typical behaviors in the CD-1 mice in a gender-andtask-specific manner.

关 键 词：双酚A 小鼠 衰老 种属行为 

分 类 号：R339.3[医药卫生—人体生理学]