支气管哮喘患儿MPO、PMN及MCP-4的血清水平及临床意义  

Serum levels and clinical significance of myeloperoxidase,neutrophils and monocyte chemoattractant protein-4 in children with asthma

作　　者：吴绍霞[1] 沈广礼[1] 王红[1] 李燕燕[1] 曾兆霞[1] 王宁[1] 

机构地区：[1]山东省临朐县人民医院,山东潍坊262600

出　　处：《中国儿童保健杂志》2014年第10期1111-1113,共3页Chinese Journal of Child Health Care

摘　　要：目的探讨外周血清过氧化物酶(myeloperoxidase,MPO)、中性粒细胞(neutrophils,PMN)及单核细胞趋化蛋白-4(monocyte chemoattractant protein-4,MCP-4)在小儿支气管哮喘的血清水平,为临床有效防治提供有效参考。方法采用酶联免疫吸附法分别测定67例支气管哮喘患儿(哮喘组)和30例健康儿童(正常对照组)血清MPO、PMN及MCP-4水平,并进行比较。结果 1)MPO的血清水平在支气管哮喘急性发作期为[(878.43±18.77)U/L]高于哮喘缓解组[(678.62±33.36)U/L]及健康对照组[(703.17±18.26)U/L](P均<0.05);2)MCP-4在支气管哮喘急性发作期患儿血清水平[(117.34±18.77)pg/mL]高于哮喘缓解组[(55.67±6.13)pg/mL]及健康对照组[(33.74±2.98)pg/mL](P均<0.05)。3)PMN绝对值在支气管哮喘急性发作期[(10.31±1.98)×109/L]高于哮喘缓解组[(4.63±1.51)×109/L]及健康对照组[(4.82±1.51)×109/L](P均<0.05)。MPO、PMN及MCP-4的升高程度与病情严重程度相关,且两者之间呈正相关(r=0.976,0.989;P均<0.01)。结论 MPO、PMN及MCP-4在支气管哮喘中发挥了重要作用,与气道炎症反应有关,血清MPO、PMN及MCP-4可做为支气管哮喘的生化检测指标。哮喘缓解期仍存在慢性炎症反应。Objective To investigate the levels of myeloperoxidase（MPO）,neutrophils （PMN） and monocyte chemoat- tractant protein-4 （MCP-4） in serum of children with bronchial asthma,and to explore the clinical significance. Method The serum levels of MPO,PMN and MCP-4 in 67 cases of bronchial asthma children （asthma group） and 30 healthy chil- dren （control group） were measured and compared by using enzyme-linked immunosorbent assay （ELSA）. Results 1） The serum level of MPO [（878.43± 18.77） U/L ]in acute exacerbation of bronchial asthma was higher than that in the re- mission group[（678.62±33.36） U/L ]and healthy controls [（703.17± 18. 26） U/L ]（P〈0.05）. 2）The serum level of MCP-4 in the acute attack of bronchial asthma children （117.34± 18. 77） pg/mL] was higher than that in the remission group （55.67±6.13pg/ml） and healthy control group [（33.74±2.98） pg/mL]（P〈0.05）. 3） The absolute value of PMN in acute attack of bronchial asthma [（10.31±1.98） × 109/L] was higher than that in the remission group [（4.63±1.51） × 10 9/L] and healthy control group [（4.82 ± 1.51） × 10 9/L] （P〈0.05）. The elevated levels of MPO, PMN and MCP-4 were related to the severity of the disease, and there was a positive correlation between the two（r= 0.976,0. 989 ;all P〈0.01 ）. Conclusions MPO,PMN and MCP-4 play an important role in bronchial asthma,and is related to airway inflammation. Ser- um MPO,PMN and MCP-4 can be used as a biochemical indexes of bronchial asthma. The remission of asthma are chronic infammatory reaction.

关 键 词：髓过氧化物酶 中性粒细胞 单核细胞趋化蛋白-4 支气管哮喘 儿童 

分 类 号：R725.6[医药卫生—儿科]