代谢综合征患者动态血压及血压变异性的研究  

The research on ambulatory blood pressure and blood pressure variability in patients with essential hypertension and metabolic syndrome

作　　者：荣瑗瑗[1] 宋达琳[1] 王丽霞[1] 陈效安[1] 康维强[1] 

机构地区：[1]山东省青岛市市立医院老年内科,山东青岛266000

出　　处：《中国医刊》2014年第10期22-24,共3页Chinese Journal of Medicine

基　　金：国家自然科学基金资助项目(81300695)

摘　　要：目的探讨代谢综合征(MS)对原发性高血压患者动态血压(ABP)及血压变异性(BPV)的影响。方法 选择80例原发性高血压患者,根据有无MS分为伴MS高血压组(38例)及单纯高血压组(42例)。对两组患者进行24小时ABP监测,比较两组患者ABP和BPV。结果与单纯高血压患者相比,合并MS的高血压患者日间平均收缩压、24小时平均收缩压显著升高;日间收缩压变异性、24小时收缩压变异性显著增大(P<0.05);而舒张压变异性差异无显著性(P>0.05)。结论原发性高血压合并MS患者日间及24小时平均收缩压较单纯高血压组增高,相应的变异性增大,这可能是其导致心血管疾病的患病率和病死率显著增加的原因之一。Objective To explore the effects of metabolic syndrome（ MS） on ambulatory blood pressure（ ABP） and blood pressure variability（ BPV） in patients with essential hypertension. Method 80 essential hypertensive patients were divided into two groups according to the definition of Mthe MS and hypertension group（n=38） and the pure hypertension group（n=42）. 24h ambulatory blood pressure was monitored in two groups,and then ABP and BPV were compared. Result Daytime（P〈0. 01） and 24h（P〈0. 05） average systolic blood pressure were significantly in-creased in the MS and hypertension group than those in the pure hypertension group. Furthermore,daytime and 24h systolic blood pressure variability were augmented in the MS and hypertension group compared to the pure hyperten-sion group（P〈0. 05）. However,there was no significant difference in diastolic blood pressure between two groups （P〉0. 05）. Conclusion MS increases daytime and 24h ABP and BPV in essential hypertensive patients,which may be one of the reasons for the increased incidence and mortality of cardiovascular disease induced by MS.

关 键 词：代谢综合征 原发性高血压 动态血压 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]