抗合成酶抗体综合征合并肺间质病1例并文献复习  

A case report of antisynthetase syndrome combined with interstitial lung disease and revelant literature review

作　　者：关岚[1] 彭丽滢[1] 李萌[1] 赵斌[1] 

机构地区：[1]北京积水潭医院急诊科,北京100035

出　　处：《中国医刊》2014年第10期28-30,共3页Chinese Journal of Medicine

摘　　要：目的提高对抗合成酶抗体综合征(ASS)合并间质性肺疾病的临床表现及治疗的认识。方法 报道1例以呼吸困难、肌痛为首发表现的ASS。检索出相关临床资料完整的病例报告28篇。结合国内外文献报道的28例同类病例的临床资料进行分析。结果 ASS常以肺部症状为首要表现,易被误诊。复习国内外文献报道的28例临床资料完整的病例,发现国内外文献报道ASS中间质性肺疾病的发病率接近90%,自身抗体谱的检测及胸部高分辨CT有助于此病的诊断。结论鉴于在抗Jo-1抗体综合征中间质性肺疾病的高发及早发,在临床工作中,对于原因不明的肺间质病变患者,可行自身抗体谱的检测及高分辨CT以早期诊断。Objective To highlight the charactertistics of antisynthetase syndrome combined with interstitial lung disease. Method The clinical and radiological data of a patient with antisynthetase syndrome combined with interstitial lung disease, and relevant literatures were reviewed. Result The antisynthetase syndrome often primarily manifested pulmonary abnormities, and was misdiagnosed as interstitial pneumonia. The onset symptoms were mostly cough, hard on breathing fever and dyspnea. Auto antibodies and High-resolution CT had great diagnostic value. Steroids and immuno-suppressants are effective. Conclusion General analysis of auto antibodies and High-resolution CT should be performed on patients with unexplained interstitial lung disease.

关 键 词：抗合成酶抗体综合征 抗Jo-1抗体综合征 间质性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]