清开灵眼用即型凝胶的制备及质量评价  

Preparation and Quality Evaluation of Qingkailing Ophthalmic in situ Gels

作　　者：付庆霞[1] 

机构地区：[1]临沂市人民医院,山东临沂276000

出　　处：《中国实验方剂学杂志》2014年第20期6-9,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81072961)

摘　　要：目的:制备温度敏感型清开灵眼用即型凝胶并对其质量进行评价。方法:采用单因素试验优选清开灵眼用即型凝胶基质,通过考察该制剂的渗透压、眼部滞留能力、黏度和体外释放度以评价其质量。结果:采用16%泊洛沙姆407与0.1%透明质酸钠的混合液作为凝胶基质时较好,清开灵注射液在9.9 min即流失完毕,而眼用即型凝胶剂的滞留时间可达30.6 min,眼部滞留能力明显延长。结论:制备的清开灵眼用即型凝胶具有良好成型性,符合即型凝胶的要求。与清开灵注射液相比,本品在用药部位停留时间较长,黏度显著增加,具有较好的缓释特性。Objective：To prepare temperature sensitive type of Qingkailing ophthalmic in situ gels and evaluate its quality.Method：Gels matrix was optimized by single factor tests,Qingkailing ophthalmic in situ gels was prepared by the 2010 edition of 〈 Chinese Pharmacopoeia）,its quality was measured by factors of osmotic pressure,eye retention capacity,viscosity and in vitro release.Result：Taking mixture of 16％ poloxamer 407 and 0.1％ sodlium hyaluronate as gel matrix,Qingkailing injections lost completely in 9.9 min,while Qingkailing ophthalmic in situ gels could stay for a longer time of 30.6 min.Conclusion：Qingkailing ophthalmic in situ gels has good formability,namely accords with requirement of in situ gels.Compared with injections,this product can stay a longer time in application site and significantly increase viscosity with a good sustained release characteristics.

关 键 词：温度敏感型 清开灵眼用即型凝胶 泊洛沙姆407 透明质酸钠 质量评价 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]