喷雾干燥法制备阿胶粉工艺  

Preparation of Ejiao Powder by Spray Drying Process

作　　者：胡永水[1] 郝向慧[1] 张淹[1] 王春艳[1] 李民[1] 

机构地区：[1]山东东阿阿胶股份有限公司,国家胶类中药工程技术研究中心,山东聊城252201

出　　处：《中国实验方剂学杂志》2014年第20期48-50,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2011ZX09201-201-10);山东省科技发展计划项目(2013G0031901)

摘　　要：目的:优选喷雾干燥法制备阿胶粉的工艺条件。方法:以干粉得率和含水量为指标,通过单因素试验和正交试验考察出风口温度、进风口温度、胶液相对密度和进料速度对阿胶粉喷雾干燥工艺的影响。结果:最佳工艺条件为相对密度1.20(60℃),进料速度40 mL·min-1,进风口温度165℃,出风口温度65℃;干粉得率和含水量分别为81.6%,4.26%。结论:优选的喷雾干燥工艺稳定可行,为阿胶颗粒、片和胶囊等剂型产品开发过程中原料干燥方法的选择提供实验依据,同时为动物胶类中药干燥方法选择提供新思路。Objective：To optimize spray drying process of Ejiao powder.Method：Taking dry powder yield and moisture content as indexes,effects of outlet and inlet air temperature,relative density of glue,feed rate on spray drying process were investigated by single factor tests and orthogonal test.Result：Optimum process conditions was as following：relative density of 1.20 （60 ℃）,feed rate of 40 mL ·min^-1,inlet air temperature 165 ℃,outlet air temperature of 65 ℃ ; dry powder yield and moisture content were 81.6% and 4.26%,respectively.Conclusion：This optimized process is stable and feasible,itcan provide experimental basis of raw material drying method selection for granules,tablets,capsules and convenient dosage forms,and it provides ideas for drying methods of animal glue oftraditional Chinese medicine.

关 键 词：喷雾干燥工艺 阿胶粉 干粉得率 含水量 

分 类 号：R283.6[医药卫生—中药学]