糖化血红蛋白水平与冠心病患者介入术后服用抗血小板药物效应的分析  

Analysis of the correlation between glycosylated hemoglobin level and antiplatelet drug efficacy in patients with coronary heart disease after percutaneous coronary intervention

作　　者：赵燕[1] 杨明[1] 崔建英[1] 金新[1] 马杰[1] 贾晓[1] 孙一光[1] 李晓红[1] 高亢[1] 

机构地区：[1]首都医科大学附属复兴医院心脏中心,北京100038

出　　处：《中国糖尿病杂志》2014年第10期914-916,共3页Chinese Journal of Diabetes

基　　金：首都发展科学基金(2009-3191)

摘　　要：目的探讨HbA1c异常是否与服用抗血小板药物效应有关。方法选取经皮冠状动脉介入治疗(PCI)术后联合服用氯吡格雷和阿司匹林1周的患者88例,采用流式细胞术和血栓弹力图检测服用阿司匹林、氯吡格雷的效应性。结果 HbA1c≥6.5%组二磷酸腺苷(ADP)、花生四烯酸(AA)抑制率低于HbA1c<6.5%组(P<0.05或P<0.01),PAC-1高于HbA1c<6.5%组(P<0.05)。结论HbA1c≥6.5组血小板活化标记物PAC-1高于HbA1c<6.5%组,高HbA1c患者氯吡格雷效应低下的概率增加,对阿司匹林效应无影响。Objective To investigate the correlation between glycosylated hemoglobin level and antiplatelet drug efficacy in patients with coronary heart disease after percutaneous coronary intervention.Methods 88 patients after percutaneous coronary intervention were enrolled.All the patients took clopidogrel and aspirin for one week after percutaneous coronary stenting.Using flow cytometry and thromboelastography to detect patients ＇ clopidogrel and aspirin efficacy.Results The ADP and AA inhibitory rate were significantly lower in HbA1c≥6.5％ group than in HbA1c＜ 6.5％ group （P＜0.05 or P＜0.01）.The PAC-1 was significantly higher in HbA1c≥6.5％ group than in HbA1 c＜ 6.5％ group （P＜0.05）.Conclusion The PAC-1 level is significantly higher in HbA1 c≥6.5％ group than in HbA1 c＜6.5％ group.High HbA1c level in patients is associated with low efficacy to clopidogrel,and no efficacy on aspirin.

关 键 词：糖化血红蛋白 CD62P PAC-1 二磷酸腺苷抑制率 花生四烯酸抑制率 

分 类 号：R541.4[医药卫生—心血管疾病]