基于聚类分析的血管源性轻度认知障碍证候要素组合研究  

Combination of syndrome factors of vascular mild cognitive impairment based on cluster analysis

作　　者：陈宝鑫[1] 金香兰[1] 郭蓉娟[1] 陈志刚[1] 高芳[1] 郑硕[1] 侯小兵[2] 赵燕[3] 张允岭[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]中国中医科学院望京医院 [3]北京中医药大学

出　　处：《北京中医药大学学报》2014年第9期629-632,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：2008年中医药行业科研专项(No.200807011);2010年中医药行业科研专项(No.201007002);北京市新医药学科群建设项目(No.XK100270569);北京中医药大学创新团队(No.2011-CXTD-23)

摘　　要：目的为聚类分析与因子分析结合探索中医证候提供参考。方法在前期血管源性轻度认知障碍中医四诊信息因子分析的基础上,计算公因子的因子得分,将24个公因子的因子得分作为变量纳入聚类分析进行指标聚类,归纳寻找该疾病的常见证候类型。结果血管源性轻度认知障碍的24个公因子可被聚为5类,结合临床经验可辨证为:肾虚证,痰热内阻证,气虚血瘀证,脾肾不足、痰浊内阻证,阴虚火旺证。结论将因子分析与聚类分析进行有机组合,能比较客观地用于中医证候研究。Objective To provide reference for studying on TCM syndromes with cluster analysis and factor analysis.Methods On the base of preliminary factor analysis on TCM four examination information of vascular mild cognitive impairment （MCI）,the scores of common factors were calculated.An index cluster analysis was conducted after including 24 common factors as variables into cluster analysis for summing up and finding common syndrome types of vascular MCI.Results The common factor of vascular MCI （n =24） were clustered into 5 types,and there were differentiated,based on clinical experience,as syndrome of kidney deficiency,syndrome of internal obstruction of phlegm-heat,syndrome of qi stagnation and blood stasis,syndrome of spleen-kidney deficiency with internal obstruction of phlegm turbidity,and syndrome yin deficiency with effulgent fire.Conclusion The organic integration of factor analysis and cluster analysis can be more objective in the studies on TCM syndromes.

关 键 词：血管源性轻度认知障碍 聚类分析 因子分析 证候要素组合 

分 类 号：R259.74[医药卫生—中西医结合]