补脾益肾法对维持性血透患者血清瘦素水平的影响  

Influence of therapy of tonifying spleen and replenishing kidney on level of serum leptin in patients with maintainance hemodialysis

作　　者：李正胜[1] 孙波[1] 卢晶晶[1] 王泽兰[1] 谢娟[1] 黄波[1] 王叶[1] 程晓娟[1] 

机构地区：[1]贵阳中医学院第二附属医院肾内科,贵州520003

出　　处：《北京中医药大学学报》2014年第9期641-643,648,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：贵州省中医药管理局资助(No.2011)

摘　　要：目的观察补脾益肾法对维持性血液透析(MHD)患者血清瘦素水平的影响,探讨补脾益肾法治疗MHD患者营养不良的机理。方法规律维持性血液透析患者60例,包括男性25例,女性35例,按随机数字法分为治疗组及安慰剂组2组。并选取同期在贵阳中医学院第二附属医院进行体检的健康人群30例作为健康组。治疗组采用补脾益肾法治疗,安慰剂组与健康组均服用安慰剂,3个月为1个疗程,共2个疗程。在试验前后分别比较健康组、治疗组、安慰剂组的血清瘦素水平。观察试验前后瘦素、血红蛋白、血清白蛋白、胆固醇等指标的变化。结果健康组在试验前后血清瘦素水平明显低于治疗组与安慰剂组(P<0.05);治疗组治疗后血清瘦素较治疗前明显降低(P<0.05)。治疗组治疗后主观综合性营养评估(SGA)评分、主症症状评分、白蛋白、胆固醇较治疗前改善(P<0.05)。上述指标治疗组与对照组比较也均有显著性差异(P<0.05)。结论补脾益肾法能有效降低MHD患者瘦素水平,改善营养状态。Objective To investigate the influence of therapy of tonifying spleen and replenishing kidney on level of serum leptin （LP） in patients with maintainance hemodialysis （MHD）,and discuss the mechanism of the therapy in treating malnutrition of MHD patients.Methods The patients （n =60,male 25 and female 35） were randomly divided into treatment group and control group,and other health persons （n =30） were chosen as normal group.The treatment group was treated with therapy of tonifying spleen and replenishing kidney,and other 2 groups were given placebo for 6 m.The level of serum LP was compared in 3 groups before and after treatment.The changes of LP,hemoglobin （Hb）,serum albumin and cholesterol （CH） were observed before and after treatment.Results The level of LP was significantly lower in normal group than that in other 2 groups before and after treatment （P ＜ 0.05）,and decreased significantly in treatment group after treatment （P ＜ 0.05）.The scores of SGA,symptom scores,and levels of serum albumin and CH were improved in treatment group after treatment （P ＜0.05）.Conclusion The therapy of tonifying spleen and replenishing kidney can effectively reduce the level of LP and improve nutritional status in patients with MHD.

关 键 词：补脾益肾法 瘦素 营养不良 维持性血液透析 

分 类 号：R259.45[医药卫生—中西医结合]