方药量效关系表现形式的研究现状与思考  

Present situation and deliberation of the dose-effect relationship of prescriptions and herb medicines

作　　者：陈弘东 赵林华[1] 沈剑刚[2] 王跃生[3,4] 徐国良[3] 仝小林[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]香港大学中医药学院,香港999077 [3]江西中医药大学,南昌330004 [4]中国中医科学院中药研究所,北京100700

出　　处：《中国新药杂志》2014年第20期2424-2429,共6页Chinese Journal of New Drugs

基　　金：国家重点基础研究发展计划("973计划")(2010CB530601)

摘　　要：目的：从目前方药量效关系的研究实验中探究方药量效关系的表现形式并思考其中原因。方法：检索中国期刊全文数据库（1979.01-2014.04）,搜集有关量效关系的临床研究及实验研究,并对其量效关系进行归纳、分析。结果：方药量效关系的表现形式是多样化的,其主要形式以量增效增、量增而效先增后减及＂量效关系多波折＂为主。讨论：量效关系表现形式多样化,究其原因可能与主治疾病不同、中药自身成分的复杂性、所监测的生物指标不同、人体的个体性（对方药吸收不同及性别差异）有关。Objective： To explore the forms and reasons of dose-effect relationship by studying the current experiments for the prescriptions and herb medicines. Methods： From the CNKI（ 1979. 01 - 2014. 04）,both clinical and experimental studies of the dose-effect relationship were searched,and the data were summarized and analyzed. Results： The forms of the dose-effect relationship were various. As the main forms,increasing dose would increase effect; increasing dose would increase effect initially and then decrease effect thereafter; twists and turns of the dose-effect. Conclusion： The forms of dose-effect relationship of prescriptions and herb medicines are various,which may result from various relations with the disease,complex compositions in Chinese medicine,different detecting biological indicators,and individual variability（ different absorption or gender）.

关 键 词：量效关系 量效表现形式 临床研究 实验研究 

分 类 号：R932[医药卫生—生药学]