AECOPD外周血CD3＋、CD4＋、CD8＋及CD16＋56＋细胞表达变化及胸腺五肽的干预作用  

Changes of peripheral CD3＋ ,CD4＋ ,CD8＋ and CD16＋ 56＋ cells in patients with acute chronic exacerbation obstructive pulmonary disease and effect of Thymopetidum intervention

作　　者：姜克家[1] 潘华琴[1] 秦少云 顾艺难[1] 陈天宇[1] 

机构地区：[1]江苏省泰州市人民医院呼吸内科,225300

出　　处：《国际呼吸杂志》2014年第19期1476-1478,共3页International Journal of Respiration

摘　　要：目的 探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者外周血CD3＋、CD4＋、CD8＋及CD16＋ 56＋细胞的表达变化及胸腺五肽的干预作用.方法 用流式细胞术分别检测AECOPD患者21例胸腺五肽干预治疗前、后和健康人对照组20例外周血CD3＋、CD4＋、CD8＋T细胞和CD16＋ 56＋ （NK）细胞的百分率,比较AECOPD患者与对照组、AECOPD患者胸腺五肽干预前、后淋巴细胞亚群的变化.结果 AECOPD患者与对照组比较,血清CD3＋、CD4＋、CD16＋ 56＋百分率、CD4＋/CD8＋明显降低,差异有统计学意义（P＜0.05）;胸腺五肽干预后与干预前比较,血清CD3＋、CD4＋、CD16＋ 56＋及CD4＋/CD8＋比值明显升高,差异有统计学意义（P＜0.05）.结论 AECOPD患者机体存在细胞免疫功能紊乱,胸腺五肽干预可提高患者免疫功能.Objective To explore the CD3＋,CD4＋,CD8＋ and CD16＋ 56＋ cells changes in patients with acute exacerbation chronic obstructive pulmonary disease（AECOPD） and effect of thymopetidum intervention.Methods Flow cytometry was used to detect the changes of CD3＋,CD4＋,CD8＋ T cells and CD16＋ 56＋ natural killer （NK） cells in peripheral blood of 21 patients at acute severe stage,these patients were treated with thymopetidum and 20 normal controls.Results The levels of serum CD3＋,CD4＋,CD16＋ 56＋ levels,CD4＋/CD8＋ in patients with AECOPD were lower than the control group,the difference was of statistically significant （P 〈 0.05）.After treatment,the CD3＋,CD4＋,CD16＋ 56＋,CD4＋/CD8＋ were increased significantly in patients with AECOPD,they are significantly different （P 〈 0.05）.Conclusions Patients with AECOPD are of cellular immune dysfunction,thymopetidum therapy can enhance the patient＇s immune function.

关 键 词：慢性阻塞性肺疾病急性加重期 T淋巴细胞 CD16+ 56+ (NK)细胞 胸腺五肽 

分 类 号：R563.9[医药卫生—呼吸系统]