血清视黄醇结合蛋白4和Apelin-12与稳定性心绞痛患者冠状动脉狭窄的相关性研究  

Relationship between association of retinol binding protein 4 and apelin-12 and coronary artery stenosis in population with stable angina

作　　者：冯俊[1,2] 高潮[1,2] 罗春苗[1,2] 张静 鲍国萍[1,2] 陈振飞[1,2] 潘建源[1,2] 江永进 侯琳琳[1,2] 

机构地区：[1]安徽医科大学附属合肥医院 [2]安徽省合肥市第二人民医院心内科,安徽合肥230011

出　　处：《安徽医药》2014年第12期2275-2278,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省高等学校省级自然科学研究项目(No KJ2013Z131)

摘　　要：目的：检测稳定性心绞痛患者血清视黄醇结合蛋白4（ RBP4）和Apelin-12水平的变化，探讨其与冠状动脉狭窄程度、病变部位的关系。方法以酶联免疫吸附法测定血清视黄醇结合蛋白4和Apelin-12水平；依据冠状动脉造影检查和Gensini评分结果分组，将Gensini积分（GS）按照四分位数间距划分为四组：GS≤18，18～32，32～47，＞47。结果与对照组比较，RBP4在GS1及GS2组中均明显高于对照组，Apelin-12明显低于对照组（P＜0．001）。与对照组比较，RBP4在单支、双支、三支病变组中均高于对照组（P＜0．001），单支、双支病变组之间差异无统计学意义（P＞0．05），但在单支与三支病变组之间差异有统计学意义（P＜0．001）；Apelin-12在单支、双支及三支病变组之间差异均有统计学意义（P＜0．001）。与对照组比较，RBP4在LAD病变组中高于对照组、Apelin-12在LAD病变组中显著低于对照组，两者在RCA、LCX病变组与对照组之间差异无统计学意义（ P＞0．05）。结论血清RBP4、Apelin-12水平和稳定性心绞痛患者冠脉病变狭窄程度有关，并且与冠状动脉病变部位有关。Objective To explore the level change of RBP 4 and apelin-12 and to investigate the relationship between changes and coro-nary artery stenosis in population with stable angina .Methods A hundred and eighteen patients who suffered from stable angina with elective coronary angiography （ CAG） ,were assigned into two groups by Gensini score （ GS） system and the stenosis of each coronary ar-tery was quantified in accordance with the four quartile range into four groups ：GS≤18,18~32,32~47,＆gt;47.Subgroups were divid-ed based on the lesions of stenosis ,the numbers and the locations of coronary artery diseased .Eighty-six individuals with normal coro-nary angiography were selected as a control group .Enzyme linked immunosorbent assay （ELISA）was used to measure the plasma Ape-lin-12 and RBP4 levels.Results Compared with control group,Apelin-12 levels were decreased and RBP4 elevated significantly in GS （P＆lt;0.001）.Compared with control group,RBP4 in single,double,triple vessel disease group was higher （P＆lt;0.05）.Single,double vessel disease was not significantly different between the groups （P＆gt;0.05）,but there was statistically significant difference between single and triple group（P＆lt;0.001）.There were significant differences in Apelin-12 among three groups（P＆lt;0.001）.Compared with control group,RBP4 was higher in the LAD lesion group ,but Apelin-12 was lower in the LAD lesion group .Both in the RCA,LCX dis-ease groups there were no statistically significant differences （P＆gt;0.05）.Conclusions Concentration changes of apelin-12 and RBP4 were induced by coronary atherosclerotic heart disease in stable angina based on the lesions ,the numbers and the locations .

关 键 词：稳定性心绞痛 视黄醇结合蛋白4 APELIN-12 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]