血管性痴呆病因病机与发病机制研究概况  

Research Survey of Vascular Dementia Etiology and Pathogenesis

作　　者：关姝明 杨晓波[2] 

机构地区：[1]甘肃中医学院针灸推拿学院 [2]甘肃中医学院针灸推拿学院针灸教研室,兰州730000

出　　处：《实用中医内科杂志》2014年第8期178-181,共4页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：血管性痴呆(vascular dementia,VD)属中医学"呆病"、"痴证"等范畴,为肾精亏虚-髓海不足、痰、浊(水湿)-瘀血等蒙蔽(阻)脑窍、玄府郁阻、浊毒内侵、本虚标实、气血亏虚、三焦气化失司、伏邪内生-损害元神、脏腑功能失调、络脉学说;病理机制包括中枢胆碱能、兴奋性氨基酸、氧自由基、神经细胞凋亡、细胞和分子(海马Ca2+、钙调素CaM依赖性蛋白激酶Ⅱ-CaMPKⅡ,内皮素-1-ET-1降钙素)、炎性反应、遗传机制、危险等。中医虽然对血管性痴呆发病原因论述较多,但机理尚未明确,未能达成共识,亦有待于临床与实验进一步检验,对呆病诊断也需扩展其内涵。认为现代医学虽在科研上取得一些研究成果,但也存在一定问题,未来应统一实验标准、设计严谨科研方案等,指导临床VD治疗,判断治法方药优劣性及稳定性。Vascular dementia is a traditional Chinese medicine, ＂dai bing＂, ＂chi dai＂ etc. The pathogenesis of shenjingkuixu-suihaibuzu, Phlegm, zhuo （shuishi）-yuxuemengbinaoqiao, xuanfuyuzu, zhuoduneiqin, benxubiaoshi, qixuekuxu, sanjiaoqihuashisi, fuxieneisheng-sunhaiyuanshen, Organs dysfunction, luomaixueshuo.The pathogenesis includes research system, excitatory amino acid, oxygen free radical, apoptosis of neural cells, the cellular and molecular mechanisms of inflammatory mechanisms, risk factors, genetic mechanism, eholinergic.Ahhough many studies of raditional Chinese medicine about the disease reason of vascular dementia, But the mechanism is not yet clear. Failed to reach a consensus, but also to be further tested in clinical and experimental, in the diagnosis of dementia should expand its connotation.Although modern medicine has made some achievements in scientific research, hut there are some problems.Future experiments should be unified design standard, rigorous scientific research programs, clinical VD treatment guidelines, judge the quality and stability of prescription drugs.

关 键 词：血管性痴呆 呆病 痴证 病因病机 中枢胆碱能 兴奋性氨基酸 氧自由基 神经细胞凋亡 海马Ca2+、钙调素CaM依赖性蛋白激酶Ⅱ(CaMPKⅡ) 内皮素-1(ET-1降钙素) 炎性反应 遗传 综述 

分 类 号：R256.11[医药卫生—中医内科学]