川芎嗪注射液联合西药治疗急性脑梗死随机平行对照研究  

Ligustrazine Hydrochloride Injection combined with Western Medicine in Treating Acute Cerebral Infarction Randomized Parallel Group Study

作　　者：刘磊[1] 陈伟[1] 杨雪山[1] 付东升[1] 

机构地区：[1]太和县中医院脑病科,安徽太和236600

出　　处：《实用中医内科杂志》2014年第9期59-61,共3页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察川芎嗪注射液联合西药治疗急性脑梗死疗效。[方法]使用随机平行对照方法,将100例住院患者按病志号抽签法简单随机分为两组。阿司匹林、清除脑自由基、脑细胞活化剂、血管内皮保护剂;颅内高压甘露醇或甘油果糖等脱水剂。对照组50例丹参注射液30mL+0.9%氯化钠250mL,1次/d,静滴。治疗组50例川芎嗪240mg+0.9%氯化钠250mL,1次/d,静滴。连续治疗14d为1疗程,间隔5d后行第2个疗程。观测临床症状、爱丁堡-斯堪的那维亚评分(MESS)、总胆固醇、同型半胱氨酸、血小板聚集率、纤维蛋白原、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组治愈18例,有效16例,显效11例,无效3例,恶化1例,总有效率92.00%。对照组治愈14例,有效12例,显效10例,无效10例,恶化4例,总有效率72.00%。治疗组疗效优于对照组(P<0.05)[结论]川芎嗪注射液联合西药治疗急性脑梗死效果显著,值得推广。[ Objective ] Ligustrazine injection combined with Western medicine in treating acute cerebral infarction. [ Method ] Random parallel control method, 100 cases of hospitalized patients were hospitalized patients were randomly divided into two groups Zhi No. simple. Aspirin, remove free radicals brain, brain cell activator, vascular endothelial protective agent ;intraeranial hypertension mannitol or glycerol fructose dehydration. A control group of 50 patients ginseng injection 30mL ＋ 0.9% sodium chloride 250mL, 1 times / d, intravenous infusion. Treatment group of 50 patients TMP 240mg ＋ 0.9% sodium chloride 250mL, 1 times / d, intravenous infusion. 14d is a continuous course of treatment interval 5d underwent the first two courses. Observation of clinical symptoms, total cholesterol, homoeysteine, platelet aggregation, fibrinogen, adverse reactions. 2 courses of continuous treatment, to determine efficacy. [ Results ] 18 cases were cured, effective in 16 cases, effective in 11 eases, 3 eases, the deterioration of one ease, the total efficiency of 92.00%. In the control group were cured 14 eases, effective in 12 eases, 10 eases, 10 eases, 4 eases of deterioration, the total efficiency of 72.00%. Treatment group than the control group （ P 〈0.05 ） [ Conclusion ] Ligustrazine injection combined with Western medicine in treating acute cerebral infarction effect is significant, it is worth promoting.

关 键 词：急性脑梗死 川芎嗪 丹参 爱丁堡-斯堪的那维亚评分(MESS) 胆固醇 同型半胱氨酸 血小板聚集率 纤维蛋白原 阿司匹林 清除脑自由基 脑细胞活化剂 血管内皮保护剂 甘露醇 甘油果糖 脱水剂 随机平行对照研究 

分 类 号：R255.2[医药卫生—中医内科学] R289.5[医药卫生—中医学]