关节软骨和骨关节炎的傅里叶变换红外光谱学显微成像研究进展  

Fourier transform infrared spectroscopic imaging on articular cartilage and osteoarthritis

作　　者：肖芝燕[1,2] 张学喜[3] 尹建华[3] 

机构地区：[1]南京航空航天大学材料科学与技术学院 [2]School of Medicine,Washington University,St.Louis MO 63110,USA [3]南京航空航天大学生物医学工程系

出　　处：《科学通报》2014年第27期2645-2651,共7页Chinese Science Bulletin

基　　金：国家自然科学基金(61378087);高等学校博士学科点专项科研基金(20133218120017);南京航空航天大学引进人才科研启动基金(1003-56YAH13005)资助

摘　　要：傅里叶变换红外光谱学显微成像(FTIRI)将傅里叶变换红外光谱测量和微区成像技术有机结合起来,同时采集样品的分子光谱和表面形貌信息,可以获得样品空间各微区位置的组成和分子结构信息.本文简述了该成像系统的构成、特点和工作原理,介绍了FTIRI在生物医学/光学领域新开辟的关节软骨光谱成像.重点介绍了该技术用于研究正常关节软骨和骨关节炎软骨所取得的代表性成果和进展,分析了部分局限性及其在该领域的未来发展前景.Fourier transform infrared spectroscopic imaging（FTIRI） system can simultaneously collect molecular spectra and morphological information by effectively integrating Fourier transform infrared spectroscopy（FTIRS） and microimaging technique. Thus, the components and molecular structure at micro-specimen can be obtained by FTIRI analysis. This paper introduced the development, operating principle and features of FTIRI, especially the research on cartilage by FTIRI that has become a new research area in biomedical optics. The typical findings and progress of the researches on normal and osteoarthritic cartilages（degeneration） by FTIRI were reviewed in detail, as well as the limitations and prospects of FTIRI in future.

关 键 词：红外光谱 显微成像 高分辨 关节软骨 骨关节炎 

分 类 号：O657.33[理学—分析化学] R684[理学—化学]