T细胞免疫球蛋白黏蛋白分子3与HBV感染的研究进展  

Research progress in TIM-3 and HBV infection

作　　者：董杰[1] 申焕君[1] 杨晓菲[1] 赵荣荣[1] 张野[1] 赵燕燕[1] 黄长形[1] 连建奇[1] 

机构地区：[1]第四军医大学唐都医院传染科,西安710038

出　　处：《临床肝胆病杂志》2014年第9期935-938,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(31370856)

摘　　要：研究发现T细胞免疫球蛋白黏蛋白分子(TIM)3与许多疾病的发病相关联。HBV感染机体时,TIM-3作为一个负性免疫调节分子,在CD8+T细胞上的表达明显增高,这表明它与HBV的发病机制密切相关。从TIM-3的生物学特性、HBV疾病转归和治疗靶点等方面回顾总结了TIM-3与HBV感染的最新研究进展,认为TIM-3将会成为HBV治疗的新靶点。Studies have found that T cell Ig- and mucin- domain- containing molecule- 3（ TIM- 3） is associated with the development of many diseases. In hepatitis B virus（ HBV） infection,TIM- 3 acts as a negative immune regulatory molecule and its expression on CD8＋T cells increases markedly. It indicates that TIM- 3 is closely related to the pathogenic mechanism of HBV infection. The latest research progress in TIM- 3 and HBV infection,including the biological characteristics of TIM- 3 and the outcomes and new therapeutic target of HBV infection,is reviewed and summarized. It is thought that TIM- 3 will become a new target in the treatment of HBV.

关 键 词：肝炎病毒 乙型 T细胞免疫球蛋白黏蛋白分子3 综述 

分 类 号：R512.62[医药卫生—内科学]