HPLC法考察注射用盐酸头孢甲肟与利巴韦林注射剂的配伍稳定性  

Compatible stability of cefmenoxime for injection with ribavirin injection by HPLC

作　　者：王建欣[1] 李敏[2] 杨继章[1] 杨媛 

机构地区：[1]河北医科大学第一医院临床药学部,石家庄050031 [2]河北联合大学附属医院药学部,唐山063000 [3]鄂尔多斯市人民医院药剂科,鄂尔多斯017000

出　　处：《中国临床药学杂志》2014年第5期292-295,共4页Chinese Journal of Clinical Pharmacy

基　　金：河北省医学科学研究重点课题(编号20120276)

摘　　要：目的考察注射用盐酸头孢甲肟与利巴韦林注射剂在氯化钠注射剂或5%葡萄糖注射剂中的配伍稳定性。方法模拟临床常用浓度,将注射用盐酸头孢甲肟用氯化钠注射剂或5%葡萄糖注射剂溶解并稀释至500 m L后再注入利巴韦林注射剂5支,在室温(25±1)℃下放置0、0.5、1、2、4、6 h后取配伍液,然后进行配伍剂外观的观察,p H值的测量和2药含量的HPLC法的测定。结果注射用盐酸头孢甲肟与利巴韦林注射剂在氯化钠注射剂或5%葡萄糖注射剂中配伍后在6 h内外观及p H值均无明显变化,头孢甲肟、利巴韦林含量均>97%。结论室温条件下,注射用盐酸头孢甲肟与利巴韦林注射剂在氯化钠注射剂或5%葡萄糖中配伍稳定。AIM To study the compatible stability of cefmenoxime for injection with ribavirin injection in sodium chloride injection and 5 % glucose injection. METHODS To simulate the clinical commonly used concentrations, HPLC was designed to determine the content after compatibility of cefmenoxime for injection and ribavirin injection, and the appearance and its pH of the mixtures were observed in 0,0.5,1,2,4 and 6 h at room temperature （25 ± 1 ） ℃. RESULTS The appearance of the mixtures was clear colorless transparent liquid within 6 h. No color change, no precipitation and gases, and no significant change were noted in pH value. The contents of both drugs in sodium chloride injection were higher than 97 %, and in 5 % glucose injection were higher than 99 %. CONCLUSION Cefmenoxime for injection and ribavirin injection are shown to be compatible within 6 h when mixed in sodium chloride injection and 5% glucose injection under room temperature. Therefore cofmenoxime for injection can be used compatibilitily with ribavirin injection in clinical.

关 键 词：头孢甲肟 利巴韦林 高效液相色谱法 配伍稳定性 

分 类 号：R96[医药卫生—药理学] O657.72[医药卫生—药学]