奥沙利铂不良反应336例分析  

Adverse drug reactions of oxaliplatin: analysis of 336 cases in our hospital

作　　者：施剑鸣 薛嵋[3,2] 吴洪斌[1,2] 陆箴琦[3,2] 胡晓文[1,2] 

机构地区：[1]复旦大学附属肿瘤医院药剂科,上海200032 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]复旦大学附属肿瘤医院护理部,上海200032

出　　处：《中国临床药学杂志》2014年第5期313-315,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的汇总分析我院奥沙利铂不良反应报告,为临床合理用药提供参考。方法收集我院2011年1月至2012年12月奥沙利铂不良反应报告336例,回顾性分析患者、疾病及不良反应信息。结果所收集的奥沙利铂不良反应以过敏反应、神经毒性和骨髓抑制为主,经处理后转归良好。不良反应报告率7.58%。结论奥沙利铂不良反应种类较多,需要临床及时监测和规范处理。AIM To analyze oxaliplatin adverse drug reaction（ADR） reports in our hospital,and to provide reference for medication safety in clinical practice. METHODS Totally 336 case reports of oxalipatin ADR from January 2011 to December 2012 in our hospital were ccllected and analyzed retrospectively. RESULTS The collected reports showed most frequent ADRs of oxaliplatin included allergic reaction, neurotoxicity and myelosuppression, which generally had good response after timely treatment. Totally ADR report ratio was 7.58 % . CONCLUSION Oxaliplatin can cause various ADRs, and need chemotherapy related professional medical care.

关 键 词：奥沙利铂 不良反应 分析 

分 类 号：R95[医药卫生—药学]