细胞的缺氧信号转导通路  

Cellular signal transduction of the hypoxia response

作　　者：韩菲菲[1] 陈国千[1] 

机构地区：[1]南京医科大学附属无锡人民医院医学检验科,无锡医学硕士研究生214023

出　　处：《医学研究生学报》2014年第9期982-985,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81070074);无锡市医管中心科研项目(YGZXQ1309)

摘　　要：缺氧是人类诸多疾病中一个重要的病理生理因素。细胞缺氧反应是细胞氧感受器感受缺氧刺激后,激活多条细胞内信号转导通路,进而调控细胞周期及机体呼吸、血液循环、能量代谢等多种生理功能的过程。细胞对缺氧的应答反应具有复杂多样性。细胞在感受缺氧、传递缺氧信号的过程中,缺氧诱导因子(Hypoxia-inducible factor,HIF)具有重要作用。激活非HIF依赖的信号转导通路在维持自身氧平衡和能量代谢平衡中也起重要作用。Hypoxia is a common physiological and pathological stimulus in many human diseases .The cellular oxygen sensors and the following activation of multiple cellular signal transduction pathways involved in hypoxia responses can regulate cell survival as well as respiration , blood circulation , metabolism and so forth .The cell response to hypoxia has a complex diversity .Hypoxia-induc-ible factor （ HIF） pathway in an oxygen dependent manner plays a central role during the hypoxia response .The HIF-independent path-ways are equally important under hypoxic conditions which can maintain the oxygen balance and metabolism balance .

关 键 词：缺氧 缺氧诱导因子-1 信号转导 

分 类 号：Q252[生物学—细胞生物学]