SHP-2及其调节破骨细胞形成作用的研究进展  

Advance research on protein tyrosine phosphatase SHP-2 and the regulating role of it in osteoclastogenesis

作　　者：林鹏[1] 姜欢[1] 胡敏[1] 

机构地区：[1]吉林大学口腔医院正畸科,长春医学硕士研究生130021

出　　处：《医学研究生学报》2014年第9期990-993,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81170999)

摘　　要：SHP-2是一种在生物体内普遍存在的具有去磷酸化作用的蛋白酪氨酸磷酸酶(protein tyrosine phosphatases,PTPs),参与多种细胞信号转导通路,其突变与多种恶性疾病有关。近年来学者发现SHP-2在破骨细胞(osteoclasts,OC)的可逆磷酸化中发挥着重要的正向调节作用,是OC形成中的关键因子。文中就SHP-2的分子生物学特征、相关疾病以及SHP-2调节OC形成的作用作一综述。SHP-2 is one of the protein tyrosine phosphatases which plays a role in the progress of dephosphorylation in organ -isms, participating in many kinds of signal transduction pathways .The mutation of SHP-2 is associated with many kinds of malignant diseases .In recent years , scholars have found that SHP-2 is the key factor in osteoclastogenesis , playing a positive role in the progress of reversible phosphorylation of osteoclasts .The objective of this article is to review the molecular biological characteristics of SHP-2, th diseases associated with the mutation of SHP-2 and the effects of SHP-2 in regulation of osteoclastogenesis .

关 键 词：蛋白酪氨酸磷酸酶 SHP-2 破骨细胞 骨代谢 

分 类 号：R68[医药卫生—骨科学]