丹参多酚酸盐对老年急性心肌梗死患者血清妊娠相关蛋白-A脑钠肽和超敏C反应蛋白的影响  

Effect of salvianolate injection on serum levels of pregnancy associated plasma protein A , brain natriuretic peptide and high sensitively C-reactive protein in elderly patients with acute myocardial infarction

作　　者：可海霞[1] 张金盈[1] 贾银明[3] 袁梦楠 刘谨春 王会玖[2] 张海柱[2] 

机构地区：[1]郑州大学第一附属医院心内科,450052 [2] 安阳市人民医院心内科 [3]安阳市中医院

出　　处：《中华老年医学杂志》2014年第10期1049-1052,共4页Chinese Journal of Geriatrics

摘　　要：目的 观察丹参多酚酸盐注射液对老年急性心肌梗死（AMI）患者血清妊娠相关蛋白-A（PAPP-A）、脑钠肽（BNP）和超敏C反应蛋白（hs CRP）浓度变化的影响. 方法 检测160例老年AMI患者以及30例健康对照者的血清PAPP A、BNP和hs-CRP浓度;老年AMI患者被随机分为丹参多酚酸盐治疗组80例和常规治疗组80例,测定两组患者治疗前、治疗2周后血清PAPP-A、BNP、hs-CRP浓度. 结果 AMI患者治疗前PAPP-A、hs-CRP和BNP浓度分别为（12.88±2.56） mg/L、（20.13±5.35） mU/L和（412.0±69.5） ng/L,均高于健康对照组（1.20±0.88） mg/L、（1.90±0.46）mU/L和（89.0±5.6）ng/L（t=24.670、3.780、11.939,均P＜0.01）.两组治疗前PAPP-A、hs-CRP和BNP浓度差异无统计学意义（t=0.864、0.712、0.985,均P＞0.05）;治疗后PAPP-A、hsCRP、BNP浓度均较治疗前降低（均P＜0.05）,且丹参多酚酸盐组治疗后PAPP-A、hs-CRP、BNP浓度分别为（3.83±1.20） mg/L、（1.33±0.38） mU/L和（105.0±31.2） ng/L,较常规治疗组（5.71±1.93）mg/L、（1.81±0.72）mU/L和（150.0±36.7） ng/L改善更明显（t=7.399、5.273、8.356,均P＜0.05） 结论 PAPP-A、hs-CRP和BNP浓度可作为观察AMI病情的临床指标;丹参多酚酸盐注射液能降低老年AMI患者血清PAPP-A、hs CRP和BNP的浓度,提示丹参多酚酸盐注射液具有抗炎及改善心功能的作用,但其作用机制仍需进一步探讨.Objective To observe the effects of salvianolate injection on blood levels of high sensitively C-reactive protein （hs-CRP）,pregnancy associated plasma protein-A （PAPP-A） and brain natriuretic peptide （BNP） in elderly patients with acute myocardial infarction.Methods The elderly patients with AMI （AMI group,n=160） and healthy controls （control group.n=30） were enrolled in this study and their blood concentrations of PAPP A,hs CRP and BNP were detected before and two weeks after treatment.The elderly patients in AMI group were randomized into conventional treatment group （n =80） and salvianolate group （n =80）.Results The levels of PAPP-A,hs-CRP and BNP were significantly higher in AMI patients [（12.88±2.56） mg/L,（20.13±5.35） mU/L,（412.0±69.5） ng/L,respectively] than in healthy subjects[（1.20±0.88） mg/L,（1.90±0.46） mU/L,（89.0±5.6） ng/L,respectively] （t=24.670,3.780,11.939,respectively,P 〈0.01）.But,before treatment there were no significant differences in the levels of PAPP-A,hs-CRP and BNP between the AMI group and control group （t=0.864,0.712,0.985,all P〉0.05）.After two weeks of treatment,as compared with control group,AMI group showed that the serum concentrations of PAPP-A,hs-CRP and BNP were decreased significantly （P〈0.05）.The levels of PAPP A,hs-CRP and BNP were （3.83±1.20） mg/L,（1.33±0.38） mU/L,（105.0±31.2） ng/L in salvianolate group and （5.71± 1.93） mg/L,（1.81±0.72） mU/L,（150.0±36.7） ng/L in conventional treatment group respectively,and the decrements in levels of PAPP-A,hs CRP and BNP were greater in the former than in the latter（t=7.399,5.273,8.356,respectively,all P〈0.05）.Conclusions The dynamic serum concentrations of PAPP-A,hs CRP and BNP can be used as clinical indexes for the prognosis of acute myocardial infarction.Salvianolate injection can significantly decrease the serum levels of PAPP A,hs CRP and BNP.The salvianolate injection may have anti inflammatory effect and improve cardiac funct

关 键 词：心肌梗死 妊娠相关血浆蛋白A 利钠肽 脑 C反应蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]