羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征效果分析  

Clinical Analysis of Hydroxychloroquine Combined with Low-Molecular-Weight Heparin and Glucocorticoids in Treatment of Pregnant Women with Antiphospholipid Syndrome

作　　者：齐莉[1] 张晓莉[1] 王晓非[1] 

机构地区：[1]中国医科大学附属盛京医院风湿免疫科,沈阳110022

出　　处：《天津医药》2014年第10期1023-1025,共3页Tianjin Medical Journal

基　　金：沈阳市科学技术项目(F12-277-1-85)

摘　　要：目的探讨羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征的安全性和有效性。方法回顾分析12例妊娠合并抗磷脂综合征患者的临床资料，其中8例结缔组织病继发抗磷脂综合征，4例原发性抗磷脂综合征，均采用羟氯喹联合低分子肝素治疗，部分联合糖皮质激素治疗。结果所有患者均顺利产下活婴，婴儿出生时无畸形，Apgar评分良好，随访2-15个月发育正常，产妇及婴儿均无不良事件发生。结论羟氯喹联合低分子肝素及糖皮质激素治疗妊娠合并抗磷脂综合征安全有效，其临床应用价值仍需进一步研究证实。Objective To investigate the safety and efficacy of hydroxychloroquine plus low-molecular-weight hep- arin and glucocorticoids in pregnant women with antiphospholipid syndrome （APS）. Methods Clinical data of 12 pregnant women with APS were retrospectively analyzed. Eight patients were APS secondary to connective tissue disease while four were primary APS. Hydroxychloroquine plus low-molecular-weight heparin was employed for the treatment of all the patients, among some of whom undergone combined glucocorticoids therapy. Results All patients underwent a successful delivery with no abnormalities and are with normal Apgar scores of the babies. No compliations were developed during a follow up of 2-15 months. Conclusion Hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids is safe and effective in treatment of pregnant women with APS, but its clinical value needs further investigate.

关 键 词：原发性抗磷脂综合征 低分子肝素 激素治疗 糖皮质 氯喹联 妊娠 临床应用价值 结缔组织病 

分 类 号：R593[医药卫生—内科学]