三维彩色血管能量成像评估乳腺癌预后  

Three-dimensional color power angiography in assessment of prognosis in breast cancer

作　　者：顾胜利[1] 陈亚青[1] 蒋珺[1] 徐依耑[1] 管雯斌[2] 

机构地区：[1]上海交通大学医学院附属新华医院超声科,上海200092 [2]上海交通大学医学院附属新华医院病理科,上海200092

出　　处：《中国医学影像技术》2014年第10期1523-1526,共4页Chinese Journal of Medical Imaging Technology

基　　金：上海交通大学医工交叉研究基金项目(YG2009MS05);上海市科委重点项目(064119632)

摘　　要：目的探讨三维彩色血管能量成像(3D-CPA)评估乳腺浸润性导管癌预后的价值。方法回顾分析82例手术病理证实的浸润性导管癌患者的3D-CPA资料,获取并比较预后相关指标不同的肿瘤间3D-CPA参数,包括肿瘤内血管指数(VI)、血流指数(FI)和血管-血流指数(VFI)差异。结果直径>2 cm、病理Ⅲ级、伴腋窝淋巴结转移、孕激素受体(PR)表达阴性肿瘤,其VI值高于直径≤2 cm、病理Ⅱ级、无腋窝淋巴结转移和PR表达阳性肿瘤(P均<0.05);直径>2 cm、雌激素受体(ER)表达阴性肿瘤FI值高于直径≤2 cm、ER表达阳性肿瘤(P均<0.05);直径>2 cm、病理Ⅲ级、PR表达阴性肿瘤VFI值高于直径≤2 cm、病理Ⅱ级和PR表达阳性肿瘤(P均<O.05);而不同人表皮生长因子-2表达肿瘤间VI、FI和VFI值差异无统计学意义(P均>0.05)。结论预后相关指标不同的乳腺癌3D-CPA参数存在差异,对预测预后具有潜在的临床应用价值。Objective To investigate the value of three-dimensional color power angiography （3D-CPA） in assessment of prognosis in invasive ductal carcinoma of breast. Methods 3D-CPA data of 82 patients with invasive ductal carcinoma confirmed by pathology were retrospectively analyzed. 3D-CPA parameters, including vascularization index （VI）, flow index （FI） and vascularization-flow index （VFI） were obtained and compared between tumors with different prognosis related factors. Results The tumors with diameter〉2 cm, grade Ⅲ , metastasis of the lymph node and negative expression of progesterone receptor （PR） showed higher VI compared with tumors with diameter 42 cm, gradeⅡ , non-metastasis of the lymph node and positive expression of PR （all P〈0.05）. The tumors with diameter〉2 cm and negative expression of estrogen receptor （ER） showed higher FI compared with tumors with diameter 42 cm and positive expression of ER （both P〈0.05）. The tumors with diameter 〉2cm, grade Ⅲand negative expression of PR showed higher VFI compared with tumors diameter 42cm, grade Ⅱ and positive expression of PR （all P〈0.05）. Tumors with different expression of human epidermal growth factor receptor 2 had no significant differences in VI, FI and VFI （all P〉0.05）. Conclusion In breast cancer, parameters of 3D-CPA have differences among tumors with different prognosis related factors, which is of use in predicting the prognosis.

关 键 词：乳腺肿瘤 超声检查 多普勒 成像 三维 预后 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]