瞬时弹性成像技术检测慢性乙型肝炎纤维化程度分析  

Analysis of transient elastography technique on the degree of chronic hepatitis B fibrosis

作　　者：张学峰[1] 许春[1] 王微[1] 

机构地区：[1]沈阳市第六人民医院肝病科一病房,110006

出　　处：《中国医师进修杂志》2014年第28期17-19,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的 探讨瞬时弹性成像技术在检测慢性乙型肝炎肝纤维化方面的实用价值.方法 选择106例慢性乙型肝炎患者.采用肝穿刺活组织检查及瞬时弹性成像技术检测.观察指标有：丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBIL）、白蛋白（ALB）、血小板（PLT）.肝穿刺活组织检查和Fibroscan结果,采用SPSS 17.0软件进行统计学分析.结果 肝硬度测定（LSM）与ALT、AST及TBIL呈正相关,与ALB、PLT呈负相关,与肝纤维化分期S呈正相关.采用LSM预测肝纤维化S4、S3、S2期的接受者操作特征曲线下面积分别为0.869 （95％ CI0.809 ～ 0.918）,0.841（95％ CI 0.810～0.901）,0.806 （95％ CI 0.747～0.866）,相应的临界值分别为22.9,14.8,10.2 kPa.结论 Fibroscan与肝纤维化有良好的相关性,LSM＞ 10.2 kPa的患者可以考虑抗病毒治疗.Objective To explore the practical value of liver transient elastography technique in the detection of chronic hepatitis B fibrosis.Methods The liver biopsy and transient elastography technique was detected in 106 patients with chronic hepatitis B.Observation index included：alanine aminotransferase （ALT）,aspartate aminotransferase （AST）,total bilirubin （TBIL）,albumin （ALB）,platelet （PLT）,statistial analysis was performed in liver biopsy and fibroscan results by SPSS17.0 software.Results Liver stiffness measurement （LSM） was positively correlated with ALT,AST and TBIL,and which was negatively correlated with ALB,PLT,and which was positively correlated with liver fibrosis stage.The area under the ROC curve by the LSM prediction of liver fibrosis S4,S3,S2 stage were 0.869 （95％ CI 0.809-0.918）,0.841 （95％ CI 0.810-0.901）,0.806 （95％ CI 0.747-0.866）,the corresponding critical value was 22.9,14.8,10.2 kPa.Conclusion There is a good correlation between fibroscan and liver fibrosis,LSM ＞ 10.2 kPa can be considered in patients with antiviral therapy.

关 键 词：瞬时弹性成像技术 肝炎 乙型 慢性 肝纤维化 

分 类 号：R512.62[医药卫生—内科学]