新型高柔顺主动脉覆膜支架实验研究  

Experiment of new compliance covered endovascular stent in sheep model

作　　者：王韧[1] 韩晓峰[2] 杨帆[2] 孙立忠[2] 黄连军[2] 徐志伟[2] 杜月河[2] 贾莲[2] 郑斯宏[2] 

机构地区：[1]福建医科大学省立临床学院福建省立医院心外科,350001 [2]首都医科大学附属北京安贞医院100029

出　　处：《中华实验外科杂志》2014年第10期2229-2231,共3页Chinese Journal of Experimental Surgery

基　　金：国家“十二五”科技支撑计划资助项目（2012BA118B00）

摘　　要：目的 探讨新型高柔顺主动脉覆膜支架在动物模型中使用的安全性和可靠性.方法 12只绵羊分为2组,每组6只,分别进行胸主动脉覆膜支架实验和腹主动脉覆膜支架实验.10 mm人工血管与绵羊腹主动脉吻合,然后经人工血管植入输送器和支架,在胸主动脉释放支架.存活30d后行胸主动脉造影,观察支架位置、形态;然后处死绵羊,进行大体解剖和病理检查.结果 所有支架均释放在所需位置,术中造影无支架移位及内漏.胸主动脉支架组有1只羊术后无法站立,术后5d死亡,尸体解剖可见支架部位血管腔内血栓形成,堵塞管腔.腹主动脉支架组有1只羊术后无法站立,术后30 d后处死,尸体解剖同样发现支架部位血管腔内血栓形成,堵塞管腔.其余羊均术后即可站立,正常活动,饮食无异常.1个月后造影,支架部位管腔通畅,支架固定在释放位置,无移位、内漏及造影剂外漏.病理检查结果证实：植入的支架与血管结合紧密,支架内壁组织光滑.结论 新型高柔顺主动脉覆膜支架在动物实验中表现了良好性能,具有安全性和可靠性.Objective In order to test feasibility and security of new compliance covered endovascular stent in sheep model.Methods 12 sheeps were divided into 2 groups：thoracic aortic stent group and abdominal aortic stent group.10 mm diameters of vascular prosthesis was end-to-side anastomosed with abdominal aorta of the sheep.Stents were transported through vascular prosthesis into thoracic aorta of the sheep.The stents were deployed in desired position of thoracic aorta.30 days later,aortogram were performed to observe position and shape of the stents.Then,the sheep were euthanized,gross and histopathologic study were executed.Results All stent were successfully deployed,no stent shifting and endoleak were observed during aortagram 30 days after operation.1 sheep died of thrombosis of the thoracic aortic stent at 5 day after stent-graft implantation.1 sheep could not walk due to thrombosis of the abdominal aortic stent after operation.Histopathologic examination：the stent were tightly combined with the aortic wall,intraluminal surface of the stent were smooth,endothelialization was observed.Conclusion New compliance covered stent was feasibility and security in sheep model.

关 键 词：动物实验 主动脉 覆膜支架 

分 类 号：R318.08[医药卫生—生物医学工程] R654.3[医药卫生—基础医学]