老年冠心病患者的血清胆红素水平  

Serum bllirubin levels In senile patlents with coronary heart disease

作　　者：张庆文[1] 苏琳[1] 李卫[1] 苗懿德[1] 

机构地区：[1]北京大学人民医院老年科,北京市100044

出　　处：《中国组织工程研究》2014年第B05期40-41,共2页Chinese Journal of Tissue Engineering Research

摘　　要：目的：观察老年冠心病患者血清胆红素水平的变化，探讨胆红素和冠心病的关系。方法：选择老年冠心病患者95例（CHD组）、健康对照者90例（对照组），测定其血清总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇水平（LDL-C），并进行比较。结果：与对照组相比，CHD 组 TBIL、DBIL、IBIL、HDL-C 明显降低（P 〈0.01），TC、LDL-C明显升高（P〈0.01），相关性分析显示，TBIL与HDL-C呈正相关，与TC、LDL-C呈负相关（P〈0.05）。Logistic回归分析显示，TBIL、HDL-C为冠心病的独立保护因素、TC、LDL-C为冠心病的独立危险因素。结论：老年冠心病患者血清胆红素水平明显低于正常人群，低胆红素水平可能为冠心病预测指标。To observe the change of Serum bilirubin （Bil） levels in senile patients with Coronary Heart Disease （CHD） and to explore the relationship between serum bilirubin levels and CHD. 95 senile patients with CHD were selected as CHD group, 90 healthy elders without CHD were selected as control group. The levels of total bilirubin （TBIL）, direct bilirubin（DBIL）, indirect bilirubin（IBIL）, total cholesterol （TC）, high density lipoprotein-cholesterol （HDL-C） and low density lipoprotein-cholesterol （LDL-C） were measured and compared between the two groups. The levels of TBIL、DBIL、IBIL、HDL-C in CHD group were significantly lower than those in control group （P〈0.01） . The levels of TC and LDL-C were significantly higher than those in control group （P〈0.01） . Pearson analysis showed that levels of TC and LDL-C were negatively correlated with TBIL levels while levels of HDL-C were positively correlated with TBIL levels （P〈0.05）. The logistic analysis showed that TBIL and HDL-C were independent protecting factors for CHD while TC and LDL-C were independent dangerious factors for CHD. The serum BIL levels in CHD patients was significantly lower than that in healthy population. Lower BIL level may be the predictive index for CHD.

关 键 词：冠心病 胆红素 胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]