绿萝花对高血脂大鼠的影响  

Studies on treatment of fatty rats animal model with Scindapsus aureus

作　　者：王赛[1] 刘群[1] 韩金潭 康莲莲[1] 杨荣[1] 

机构地区：[1]西南民族大学生命科学与技术学院,成都610041

出　　处：《中药药理与临床》2014年第4期84-88,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家"十二五"科技支撑计划项目(2011BAD34B02-4);中央高校基本科研业务费科研建设平台(11NPT03)

摘　　要：目的:研究藏药绿萝花对高血脂症大鼠动物模型的治疗作用,为临床合理用药和开发提供实验依据。方法:本研究采用饲喂高脂乳剂创建SD大鼠高血脂动物模型,将实验动物分成对照组、模型组、非诺贝特胶囊组(40mg/kg)及灌服绿萝花提取物组(剂量分别为50g/kg、25g/kg、12.5g/kg),分别在实验的第14、21、28、35、42d,以血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)和抗动脉硬化指数(AAI)为检测指标,研究绿萝花降血脂作用。结果:造模两周,模型组、非诺贝特胶囊组、50g/kg、25g/kg、12.5g/kg剂量绿萝花组的TC值显著高于对照组;连续给予三周的非诺贝特胶囊和不同剂量的绿萝花,使AAI值较之模型组的AAI值下降趋势减缓;连续给药四周,非诺贝特胶囊组和50g/kg剂量绿萝花组TC值极显著低于模型组,各组间的LDL-C值无显著性差异,50g/kg剂量绿萝花组能抑制高血脂大鼠血清LDL-C值升高。结论:绿萝花通过降低高脂乳剂诱导的高脂血症SD大鼠血清TC含量、抑制血清LDL-C上升、恢复高脂血症低下的AAI的作用而达到治疗高脂血症的目的。Study the treatment role of Scindapsus aureus on fatty rats animal model and provide experimental bases for reasonable clini- cal medication and development. Methods： To make the fatty SD rats animal model, we fed high fat emul to them. Experimental animal were divided into six groups： control group, model group, fenofibrate capsules group （10 g/kg） ,2g/ml, l g/ml,0.5g/ml of Scindapsus aureus ex-tractive. To study the role of Scindapsus aureus in hypolipidemic , we used these index： triacylglycerol（ TG）, total cholesterol（TC） ,low densi- ty lipoprotein cholesterin（LDL-C） ,high density lipoprotein cholesterol（ HDL-C ）and antiarterial hardness indices （AAI）in the 14st day, the 21st day,the 28st day,the 35st day,the 42st day. Results： At 14 days after modeling,the TC value of model control group, fenofibrate cap- sules group ,2g/ml dose group, 1 g/ml dose group and 0.5g/ml dose group were significant higher than that in blank control group（ P 〈 0.05 ） ; the AAI value falling slowly through continuous to give fenofibrate capsules and different dose of Scindapsus aureus than that in model control group for three weeks; Successive medication for four weeks, the TC value of fenofibrate capsules group and 2g/ml dose group were highly sig- nificant lower than that in model control group（ P 〈 0.01 ） , There was no significant difference in LDL-C value（ P 〉 0.05 ） , but 2g/ml dose herb medicine could have an effect on inhibition of increasing of serum hyperlipidemia rats LDL-C value. Conclusion： Scindapsus aureus can treat hyperlipidemia through reducing hyperlipidemia serum TC value which was induced by high-fat emulsion,inhibition of rising of hyper- lipemia rat LDL-C value and restoring the low of AAI caused by hyperlipemia.

关 键 词：绿萝花 高血脂症 治疗作用 

分 类 号：R285.5[医药卫生—中药学]