PET/MRI与PET/CT在人体生理器官SUVmax的比较  

Validation of standardized uptake values for 18F-FDG in normal organs： comparison of whole-body PET/CT and PET/MRI

作　　者：富丽萍[1] 刘家金[1] 尹大一[1] 张锦明[1] 陈英茂[1] 安宁豫[2] 徐白萱[1] 田嘉禾[1] 

机构地区：[1]解放军总医院核医学科,北京100853 [2]解放军总医院南楼放射科,北京100853

出　　处：《中华医学杂志》2014年第37期2934-2937,共4页National Medical Journal of China

摘　　要：目的 通过PET/CT与PET/MRI在人体器官放射性摄取值（SUVmax）的配对比较,评价PET/MRI定量分析的能力.方法 选择2012年5月至2013年2月解放军总医院同日PET/CT和PET/MR检查且临床及影像学资料完整的277例患者.以右肺、肝右叶,第3腰椎椎体及竖脊肌为参考区,将感兴趣区（ROI）分别置于PET衰减校正后图像,获得SUVmax-CT和SUVmax-MRI.相同的ROI也置放于双时间点PET/CT图像的肝脏和竖脊肌.采用配对符号秩和检验以及Spearman相关性分析评价两组SUV max之间的关系.结果 57例受试者未见异常征象,220例患者中经病理证实259例恶性及21例良性病灶.除了肺部（r=0.44）,SUVmax-CT和SUVmax-MRI在其他3个器官均存在高度相关（r =0.62～0.73）.4个组织器官SUVmax-MRI均明显低于SUVmax-CT（P＜0.01）.延迟校正后,肝脏及肌肉两组SUV之间差异仍有统计学意义（P＜0.01）.结论 尽管SUVmax-MRI与SUVmax-CT存在差异,但是两者高度相关,提示PET/MRI均能提供可靠的定量诊断信息.Objective To validate whether PET/MR could provide a semi-quantitative measurement （SUVmax） comparable to that produced by PET/CT in normal organs.Methods 277 subjects underwent an ordinary 18F-FDG PET/CT followed by a PET/MR scan with a 25-45 min interval.Region of interest （ROIs） were drawn in 4 reference normal organs/tissues in both MRAC-PET and CTAC-PET images and the liver and erector spinae in the dual-time point PET/CT images.Results 259 malignant and 21 benign lesions,pathologically confirmed,were detected in the 220 subjects.SUWmax derived from PET/CT （SUVmax-CT） and PET/MR （SUVmax-MRI） was highly correlated over the reference organ ROIs （r =0.62-0.73）,except lung （r =0.44）.The SUVmax-MRI was significantly lower than the respective SUVmax-CT in all 4 organs and after delay-correction in liver and muscle.Conclusion The results indicate that PET/MR can provide reliable measurement in physiological organs.

关 键 词：正电子发射断层显像术 肿瘤 氟脱氧葡萄糖F18 

分 类 号：R445.2[医药卫生—影像医学与核医学] R817.4[医药卫生—诊断学]