COPD定量CT扫描与肺功能检查小气道参数的相关性研究  

Small Airway Parameters of Chronic Obstructive Pulmonary Disease: Correlation between Quantitative CT and Pulmonary Functional Tests

作　　者：夏亭亭[1] 关玉宝[1] 李靖煦[1] 万齐[1] 周嘉旋 李宏[2] 孙申申[2] 康雁[2] 

机构地区：[1]广州医科大学附属第一医院放射科,广州510120 [2]东北大学中荷生物医学与信息学院,沈阳110819

出　　处：《CT理论与应用研究（中英文）》2014年第4期591-599,共9页Computerized Tomography Theory and Applications

基　　金：国家自然科学基金(81371633);广东省教育厅学科建设专项资金项目(2013KJCX0150);广州市科技攻关专项项目(201300000190)

摘　　要：目的:探讨慢性阻塞性肺疾病(COPD)定量CT肺功能参数与肺功能检查(PFT)小气道参数的相关性。方法:28例COPD患者,分别采用最大吸气相和最大呼气相螺旋CT扫描,分析定量CT参数及肺功能检查(PFT)小气道参数之间相关性。结果:COPD定量CT肺功能成像参数中的吸气相平均肺密度(MLD)、呼气相MLD、吸气相肺气肿体积(EV)、呼气相EV、吸气相肺气肿像素指数(EI)及呼气相EI与肺功能FEV1/FVC的相关性最好(r分别为0.44、0.64、-0.50、-0.66、-0.57、-0.64,P<0.01),最大呼气相肺体积Vex与肺功能FEV1(%P)相关性最好(r=-0.48,P<0.01),呼气相MLD与PEF(%P)(肺功能呼吸峰流速占预计值百分比)相关性最好(r=0.40,P<0.05),最大呼气相肺体积Vex、呼气相MLD、呼气相EV与肺功能FEF25%FVC(%P)相关性最好(r分别为-0.40、0.44、-0.41,P<0.05),呼气相MLD、呼气相EI与肺功能MMEF相关性最好(r分别为-0.57、0.50,P<0.01)。结论:采用最大吸气相和最大呼气相螺旋CT扫描获得的肺部定量参数和PFT小气道功能参数具有相关性,且呼气相优于吸气相。Objective： To evaluate the correlation between COPD quantitative CT pulmonary function parameters and PFT parameters. Methods： 28 cases of COPD patients, using the maximal inspiratory and maximum expiratory phase spiral CT scanning to analysis the correlation between quantitative CT parameters and pulmonary function test（PFT） parameters. Results： The correlation between COPD quantitative CT pulmonary function parameters of inspiratory phase average lung density, expiratory phase average lung density, inspiratory phase emphysema volume, expiratory phase emphysema volume, inspiratory phase emphysema pixel index, expiratory phase emphysema pixel index and pulmonary function of FEV1/FVC is best（r value respectively 0.44, 0.64, 0.50,0.66, 0.57, 0.64, P〈0.01）. The correlation between maximum expiratory phase lung volume and lung function FEV1%（P） is best（r = 0.48, P〈0.01）. The correlation between expiratory phase average lung density and lung function PEF（% P） is best（r = 0.40, P〈0.05）. The correlation between maximum expiratory phase lung volume, expiratory phase average lung volume density, expiratory phase emphysema and pulmonary function best FEF25% FVC%（P） is best（r value respectively 0.40, 0.44, 0.44, P〈0.05）. The correlation between expiratory phase average lung density, expiratory phase emphysema pixel index and pulmonary function MMEF is best（r value respectively-0.57, 0.50, P〈0.01）. Conclusion： The quantitative parameters with maximal inspiratory phase and maximum expiratory phase helical CT scanning have a correlation with small airway PFT parameters, and expiratory phase is better than that of inspiratory phase.

关 键 词：慢性阻塞性肺疾病 小气道病变 定量CT 肺功能检查 

分 类 号：R563.9[医药卫生—呼吸系统] R816.41[医药卫生—内科学]