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机构地区:[1]湖南中医药高等专科学校附属第一医院,湖南株洲412008
出 处:《湖南中医杂志》2014年第9期15-17,共3页Hunan Journal of Traditional Chinese Medicine
基 金:湖南省中医药管理局资助项目(编号:2008060)
摘 要:目的:观察角黄汤肠道滴入治疗早中期慢性乙型重型肝炎的临床疗效。方法:将119例早中期慢性乙型重型肝炎患者随机分为治疗组59例、对照组60例。对照组以常规西药治疗,治疗组以常规西药联合角黄汤肠道滴入治疗。观察患者肝功能、凝血功能、内毒素、血氨变化及并发症、生存率等情况。结果:总有效率治疗组为86.44%,对照组为68.33%,两组比较,差异有统计学意义(P<0.01);治疗组可降低早中期慢性乙型重型肝炎患者ALT、AST、TBIL、ET、血氨水平,提高白蛋白含量及生存率,提高凝血酶原活动度,并减少并发症的出现;与对照组相比,治疗组改善程度更为显著(P<0.05或P<0.01)。结论:角黄汤肠道滴入治疗可有效改善早中期慢性乙型重型肝炎患者肝功能及凝血功能,减少并发症发生,提高患者生存率。Objective:To observe the clinical efficacy of intestinal infusion of Jiaohuang decoction in treating early - and middle -stage chronic severe hepatitis B. Methods:A total of 119 patients with early - and middle - stage chronic severe hepatitis B were randomly divided into treatment group (n = 59) and control group (n = 60). The control group received conventional Western medicine treatment, while the treatment group received intestinal infusion of Jiaohuang decoction in addition to conventional Western medicine treatment. The changes in liver func- tion,coagulation function ,endotoxin (ET),and blood ammonia, as well as complications and survival rate ,were e- valuated. Results:The treatment group had a significantly higher overall response rate than the control group (86.44% vs 68.33% ,P 〈 0. 01 ). The treatment group showed decreases in the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, ET, and blood ammonia and the incidence of complications and increases in albumin level, survival rate, and prothrombin activity. Compared with the control group, the treatment group showed significantly more improvements (P 〈 0.05 or P 〈 0.01 ). Conclusion:For patients with early - and middle - stage chronic severe hepatitis B, intestinal infusion of Jiaohuang decoction can effectively improve the liver func- tion and coagulation function, reduce the incidence of complications, and increase the survival rate.
关 键 词:慢性乙型重型肝炎 早中期 中医药疗法 角黄汤 肠道滴入 生存率
分 类 号:R259.126.2[医药卫生—中西医结合]
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