僵卿金沸草散治疗咳嗽变异性哮喘疗效观察  

Observation on Therapeutic Effects of JiangQing JinFeiCao Powder in the Treatment for Cough Variant Asthma

作　　者：严文有 李有成 赵斌庆 王志超 

机构地区：[1]武威市计划生育技术服务站,甘肃武威733000

出　　处：《西部中医药》2014年第9期97-99,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察僵卿金沸草散治疗咳嗽变异性哮喘的临床疗效及其对血清中LTB4、IL-4表达的影响。方法:将咳嗽变异性哮喘患者60例随机分为2组各30例,治疗组口服僵卿金沸草散治疗:对照组口服孟鲁司特、酮替芬治疗。观察2组患者用药前后症状、体征变化情况并检测LTB4、IL-4的表达水平。结果:治疗组显效22例,有效6例,无效2例,总有效率93.33%,对照组显效20例,有效6例,无效4例,总有效率86.67%,治疗组临床疗效优于对照组;LTB4、IL-4 2组治疗前比较差异无统计学意义(P>0.05),治疗后组内比较差异显著(P<0.01)。结论:僵卿金沸草散治疗咳嗽变异性哮喘,可能通过抑制LTB4、IL-4的表达水平,维持Th1/Th2平衡,从而控制气道炎症,减少咳嗽变异性哮喘的发作,疗效优于孟鲁司特、酮替芬。Objective： To explore curative effects of JiangOing JinFei Coo powder in the treatment for cough variant asthma and its influence on the expressions of LTB4 and IL-4. Methods： Sixty patients were randomized into two groups, 30 cases of the treatment group took JiangQing JinFei Coo powder, the control group montelukast and ketotifen. Syinptom and body signs of the patients in both groups were observed before and after administration, the expressions of LTB4 and IL-4 were detected. Results： In the treatment group, there were 22 cases markedly effective, six cases effective, two cases ineffective, and total effective rate 93.33%, there were 20 cases markedly effective, six cases effective, four cases ineffective, and total effective rate 86.67%, clinical effects of the treatment group were superior to these of the control group; the difference had no statistical meaning in the comparison of LTB4 and IL-4 before treating （P〉0.05）, the difference was significant in the comparison within one group after treating （/9〈 0.01）. Conclusion： JiangOing JinFei Coo powder is superior to montelukast and ketotifen for cough variant asthma, it could control the inflammation of air passage and reduce the attack of cough variant asthma, which might be through inhibiting the expressions of LTB4 and IL-4, maintaining the balance between Thl/Th2.

关 键 词：咳嗽变异性哮喘 LTB4 IL-4 姜卿金沸草散 

分 类 号：R562.2[医药卫生—呼吸系统]