阿托伐他汀联合强骨胶囊对老年2型糖尿病性骨质疏松症的疗效观察  

Clinical observation of atorvastatin combined with Qianggu capsules in the elder patients with type 2 diabetic osteoporosis

作　　者：罗娟[1] 秦爱平[1] 赵新兰[1] 陈凯[1] 李文静[1] 

机构地区：[1]湖南省马王堆医院内分泌科,长沙410016

出　　处：《疑难病杂志》2014年第10期1001-1003,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：湖南省科技基本项目投资计划[2012]1493号

摘　　要：目的观察阿托伐他汀联合强骨胶囊治疗老年2型糖尿病性骨质疏松症的疗效。方法 100例老年2型糖尿病性骨质疏松症患者按数字法随机分为2组,每组50例。治疗组口服阿托伐他汀和强骨胶囊;对照组给予口服强骨胶囊,2组均予以联合服用碳酸钙/维生素D_3,均服用药物6个月。观察2组临床疗效,评价治疗前和治疗后的疼痛评分情况及骨密度(BMD)情况。结果与治疗前比较,2组治疗后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA_(1c))均有改善,差异有统计学意义(P<0.05);而BMI无显著变化(P>0.05),2组比较差异亦无统计学意义(P>0.05)。与治疗前比较,2组疼痛评分均下降[分别为(7.96±2.73)分vs.(3.68±1.76)分、(7.89±2.90)分vs.(5.26±1.65)分,P均<0.01];且治疗组下降幅度高于对照组(P<0.05);与治疗前比较,治疗后治疗组BMD明显改善(P<0.05),而对照组无显著改善(P>0.05),且治疗组治疗后BMD改善优于对照组(P<0.05)。结论阿托伐他汀联合强骨胶囊治疗老年2型糖尿病性骨质疏松症具有协同作用。Objective To observe the curative effect of atorvastatin combined with Qianggu capsules in the treatment of elderly patients with type 2 diabetic osteoporosis. Methods 100 cases of elderly patients with type 2 diabetic osteoporosis were randomly divided into 2 groups, 50 cases in each group. The treatment group received oral atorvastatin and Qianggu capsules ; the control group was given orally Qianggu capsules, 2 groups were treated with combined use of calcium carbonate Vitamin D3 , both groups were taking medication for 6 months. Observed the clinical curative effect of the pain scores and the bone density evaluation before and after treatment （BMD） condition in the 2 groups. Results Compared with pre and post treatment, fasting plasma glucose （FPG）, postprandial 2 h blood glucose （2 hPG） , HbA1c in the 2 groups were improved, the difference was statistically significant （ P 〈 0. 05 ） , and BMI showed no significant change （ P 〉 0.05 ）, the difference between the 2 groups has no statistical significance （ P 〉 0.05 ）. Compared with before treatment,2 groups＇ pain scores were decreased [（7.96±2.73） vs. （3.68±1.76）, （7.89±2.90） vs. （5.26±1.65）, P 〈0.01],the treatment group decreased more obvious than control group（ P 〈 0.05 ） ;compared with before treatment, bone density were improved in treatment group（ P 〈 0.05 ） , while no significant improvement were found in control group （ P 〉 0. 05 ）. Compared with the control group, the treatment group＇s pain scores, lumbar spine and femoral neck BMD were improved obviously, the difference was statistically significant （ P 〈 0.05 ）. Conclusion Atorvastatin has a synergistic effect on Qianggu capsules in the treatment of elderly patients with type 2 diabetic osteoporosis therapy.

关 键 词：糖尿病 2型 骨质疏松 阿托伐他汀 强骨胶囊 老年人 

分 类 号：R587.1[医药卫生—内分泌] R580[医药卫生—内科学]